Clonatril 1mg 10pcs

Clonazepam (Oral) is indicated in:

• Anxiety disorders (Generalized, Phobic & Panic disorders)
• Insomnia and sleep disturbances
• Labile arterial hypertension
• Peri and Post menopausal anxiety (Anxiety in middle aged women)
• Burning Mouth Syndrome
• Peri and Post menopausal anxiety (Anxiety in middle aged women)
• Postoperative anxiety disorder

Clonazepam (Injection) is indicated in:

• Epilepsy
• Status epilepticus
• Myoclonic seizure
• Typical and atypical absences (Lennox-Gastaut syndrome)
• Infantile spasm
• Tonic-clonic seizure
• Partial seizure
• Absence seizure
• Focal seizure

Adjunct anti-epileptic drugs, Benzodiazepine hypnotics

Clonazepam reduces the nerve transmission in the motor cortex which suppresses the spike and wave discharge in absence seizures. Its mechanism is believed to be related to its ability to enhance the activity of GABA. Clinically, it improves focal epilepsy and generalised seizures.

Dosage must be determined in each patient according to clinical response and tolerance.

Oral:

Children: The initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day and should not exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by not more than 0.25 to 0.50 mg every third day until a maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the larger dose should be given before retiring.

Adults: 1 mg (elderly 500 micrograms) initially at night for 4 nights, increased according to response over 2-4 weeks to usual maintenance dose of 4-8 mg usually at night (may be given in 3-4 divided doses if necessary). Dosage may be increased in increments of 0.5 to 1 mg every three days until seizures are adequately controlled. A recommended maintenance dose for adults is 8 to 10 mg/day in three divided doses. Dosages in excess of 20 mg/day should be administered with caution.The use of multiple anticonvulsants may result in an increase of depressant adverse effects.This should be borne in mind whenever Clonazepam is added to an already existing anticonvulsant regimen.