Indications
A-Mycin is highly effective in the treatment of a wide variety of clinical infections, such as
1.Upper respiratory tract infections: Tonsillitis, peritonsillar abscess, pharyngitis, laryngitis, sinusitis, and secondary infections in cold and influenza.
2.Lower respiratory tract infections: Tracheitis, acute and chronic bronchitis. Mycoplasma pneumoniae (lobar pneumonia, broncho pneumonia, primary atypical pneumoniae), bronchiectasis.
3.Skin and soft tissue infections: Boils and carbuncles, paronychia, abscesses, pustular acne, impetigo, cellulitis, furuncolosis, erythrasma.
4.Veneral infections: Non-specific urethritis, syphilis (if the patient is allergic to penicillin).
5.Gastro-intestinal infections: Cholecystitis, Staphylococcal enterocolitis, infectious diarrhoea, & cholera.
6.Ear and oral infections: 0titis media and otitis externa, gingivitis, dental abscesses.
7.Prophylaxis: Pre-operative and post-operative, trauma, burns, rheumatic fever.
8.Other infections: Diphtheria, whooping cough.
Dosage & Administration
Adults: Usually 250 mg every 6 hours, or 500 mg every 12 hours. May increase up to 4 g/day, according to severity of infection.
| Infections | Dosage and Administration |
|---|---|
| Upper respiratory tract infections of mild to moderate severity | 250 to 500 mg 4 times a day for 10 days |
| Lower respiratory infections of mild to moderate severity | 250 to 500 mg 4 times a day for 10 days |
| Respiratory tract infections due to Mycoplasma pneumoniae | 500 mg 6 hours for 5 to 10 days, treat severe infections for up to 3 weeks |
| Skin and soft tissue infections of mild to moderate severity | 250 to 500 mg 4 times a day for 10 days |
| Pelvic inflammatory diseases (PID), acute due to Neisseria gonorrhoeae | 500 mg 4 times a day for 10 to 14 days |
| Urogenital infection during pregnancy caused by Chlamydia trachomatis | 500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days |
| Urethral, endocervical or rectal infections, uncomplicated | 500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days |
| Non-gonococcal urethritis | 500 mg 4 times daily for at least 7 days |
| Neisseria gonorrhoeae: Uncomplicated urethral, endocervical or rectal infections and in penicillinase producing N. gonorrhoeae(PPNG) | 500 mg 4 times a day for 7 days |
| Early syphillis (primary, secondary or latent syphillis of < 1 year duration) | 500 mg 4 times a day for 14 days |
| Severe or chronic diarrhoea | 500 mg 4 times a day for 7 days |
| Rheumatic fever | 250 mg 2 times daily |
| Bacterial endocarditis | 1 g 2 hours prior to procedures, then 500 mg 6 hours after initial dose |
| Acne | 500 mg twice daily for 3 months reduced to 250 mg twice for 3 months |
Children:
The usual oral dose is 30-50 mg/kg body weight per day in divided doses. For more severe infections, the dose may be doubled.
Side Effects
Gastro-intestinal: Abdominal cramp & discomfort, nausea, vomiting & diarrhoea. Hypersensitivity reaction may also be responsible for the hepatotoxicity sometimes in patients receiving Erythromycin or its derivatives.
Contraindications
Erythromycin is contraindicated in patients with known hypersensitivity of this antibiotic.
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