Treatment of all patients with type 1 diabetes. Treatment of patients with type 2 diabetes who are not adequately controlled by diet and/ or oral hypoglycemic agents.
For the initial stabilization of diabetes in patients with diabetic ketoacidosis, hyperosmolar non-ketotic syndrome and during periods of stress such as severe infections and major surgery in diabetic patients. Treatment of gestational diabetes.
Insulin Human (rDNA) is human insulin made by recombinant DNA technology. It has the same structure and function as natural insulin. Insulin regulates the glucose metabolism and stimulates the ingestion and utilization of glucose by liver, muscle and fat tissue. It also lowers blood glucose by accelerating glycogenesis and inhibiting gluconeogenesis.
Insulin Human (rDNA) R starts action within 30 minutes after injection, reaches its peak within 1.5-3.5 hours and lasts about 7-8 hours. Insulin Human (rDNA) N starts action within 1.5 hours after injection, reaches its peak within 4-12 hours & lasts about 24 hours.
The average range of total daily insulin requirement for maintenance therapy in type 1 diabetic patients lies between 0.5 and 1.0 IU/kg. In pre-pubertal children it usually varies from 0.7 to 1.0 IU/kg, whereas in insulin resistant cases, e.g. during puberty or due to obesity, the daily insulin requirement may be substantially higher. Initial dosages for type 2 diabetic patients are often lower, e.g. 0.3 to 0.6 IU/kg/day.
The dosage form, the dosage and the administration time of the insulin are different due to the individual differences of each patient. In addition, the dosage is also affected by food, working style and exercising intensity. Therefore, patients should use the insulin under doctor’s instruction.
An injection should be followed by a meal or snack containing carbohydrates within 30 minutes. Injection is administered subcutaneously in the upper arm, thigh, buttock or abdominal wall. A subcutaneous injection into the abdominal wall results in a faster absorption than from other injection sites. Insulin Human (rDNA) R can be given intravenously only by the physician in emergency situations. However, Insulin Human (rDNA) N, is never to be administered intravenously.
Preparation before use:
- Clean your hands.
- Shake or rotate the vial gently to mix the solution uniformly and check if the insulin has the normal appearance.
- In case of using a new vial, flip off the plastic protective cap and wipe the rubber plug with an alcohol swab.
- Draw air into your syringe equal to the amount of insulin needed.
- Puncture the needle into the vial and inject the air.
- Turn the bottle and syringe upside down and withdraw correct dose of insulin into the syringe.
- Before pulling out the needle, check if there are any bubbles remain in the syringe. If so, put the syringe upright and tap the syringe to discharge the air bubbles.
- Choose the area where skin is less tight, such as the upper arm, thigh, buttock or abdomen.
- To avoid tissue damage, choose a site for each injection that is at least 1 cm from the previous injection site.
- Cleanse the skin with alcohol where the injection is to be made.
- Put the needle in such a position as to form 45° angle with the skin.
- Puncture the needle into skin and inject insulin.
- Keep the needle under the skin for at least 6 seconds to make sure the entire dose is injected.
- Pull the needle out and apply gentle pressure over the injected site for several seconds.
- Do not rub the injection site.