Afrin 0.25%

Oxymetazoline Hydrochloride is applied topically to relieve nasal congestion associated with acute or chronic rhinitis, common cold, sinusitis, and hay fever or other allergies. It is also used as nasal decongestant in otitis media.

Nasal Anti-histamine preparations, Nasal Decongestants & Other Nasal Preparations

Oxymetazoline is a direct-acting sympathomimetic which has vasoconstrictor effect on mucosal blood vessels when applied topically and in turn reduces oedema of the nasal mucosa.

Adults and children 6 years of age and older: 2-3 drops or sprays in each nostril twice daily for 3-5 days.Children of age 2-6 years: 2-3 drops in each nostril twice daily for 3-5 days. Sprays are generally unsuitable for young children because of the small size of their nostrils. The drug is not recommended in children under the age of 2 years.

The nasal spray can be used with the patient in the upright position. Sprays are generally unsuitable for young children because of the small size of their nostril. A treatment course should not normally exceed three to five days, and on no account should it be continued for longer than two weeks because of the risk of developing “rhinitis medicamentosa”.

Monoamine oxidase inhibitors (MAOIs): Concomitant use of oxymetazoline and MAOI can result in  hypertensive reaction.Tricyclic antidepressants (TCAs): TCAs may increase the effects of oxymetazoline on blood pressure.

Contraindicated in patients hypersensitive to Oxymetazoine Hydrochloride.

Transient burning, dryness of the nasal mucosa, sneezing, Nervousness, dizziness, headache, Hypertension, palpitation or reflex bradycardia.

Pregnancy: Safe use of oxymetazoline during pregnancy has not been established; it should be avoided by pregnant women.Nursing Mother: It is not known whether oxymetazoline is secreted in human breast milk; caution is advised.