INDICATION
Anadol
® (Tramadol) is used for the treatment of moderate to severe painful conditions.
These include: Postoperative pain, Colic and spastic pain, Cancer pain, Joint pain, Neck
and back pain & Pain associated with osteoporosis.
DOSAGE AND ADMINISTRATION
Anadol
® Capsule:Usual doses are 50 to 100 mg every four to six hours. For acute pain an
initial dose of 100 mg is required. For chronic painful conditions an initial dose of 50 mg
is recommended. Subsequent doses should be 50 to 100 mg administered 4-6 hourly.
The dose level and frequency of dosing will depend on the severity of the pain.The total
daily dosage by mouth should not exceed 400 mg.
Anadol
® 100 SR capsule: One SR capsule every 12 hours, for example first one in the
morning and then at the same time in the evening. The number of capsules taken at a
time will depend upon severity of pain, but it should not be taken more frequently than
every 12 hours.The total daily dosage by mouth should not exceed 400 mg.
Anadol
® 100 Injection: A dose of 50-100 mg may be given every 4 to 6 hours by
intramuscular or by intravenous infusion. For the treatment of postoperative pain,the initial
dose is 100 mg followed by 50 mg every 10 to 20 minutes if necessary to a maximum of 250
mg in the first hour.Thereafter, doses are 50 to 100 mg every 4 to 6 hours up to a total daily
dose of 600 mg.
Anadol
® 100 Suppository: Anadol® suppository should be administered rectally. For adults
usual dose is 100 mg Tramadol Hydrochloride 6 hourly. In general, 400 mg Tramadol
Hydrochloride (= 4 Anadol® suppository) per day sufficient. However, for the treatment of
Cancer pain and severe pain after operations much higher daily doses can be used.
SIDE EFFECT
Commonly occurring side effects are dizziness/vertigo, nausea, constipation, headache,
somnolence, vomiting, pruritus, CNS stimulation, asthenia, sweating, dyspepsia, dry
mouth, diarrhoea. Less commonly occurring side effects include malaise, allergic
reaction, weight loss, vasodilatation, palpitations, abdominal pain, anorexia, flatulence,
GI bleeding, hepatitis,stomatitis etc.
CONTRAINDICATION
Tramadol is contraindicated in persons having hypersensitivity to this drug. It is also
contraindicated in acute intoxication with alcohol, hypnotics, centrally acting analgesics,
opioids or psychotropic drugs.
DRUG INTERACTION
In general, physician need not be concerned about drugs interacting with Tramadol.The
monoamine oxidase (MAO) inhibitors represent the only drug class not recommended
for combination with Tramadol. Concomitant administration of carbamazepine with
Tramadol causes a significant increase in Tramadol metabolism and it requires to
increase the dose of Tramadol.
PRECAUTION
Respiratory depression: When large doses of Tramadol are administered with anaesthetic
medications or alcohol, respiratory depression may result. Therefore, Tramadol should be
administered cautiously in patients at risk for respiratory depression.
Opioiddependence:Tramadol is notrecommended forpatientswho are dependent on opioids.
Concomitant CNS depressants: Tramadol should be used with caution and in reduced
dosages when administering to patients receiving CNS depressants such as alcohol,
opioids, anesthetic agents,phenothiazines,tranquilizers orsedative hypnotics.
Concomitant MAO inhibitors: Tramadol should be used with great caution in patients
taking MAO inhibitors, since Tramadol inhibits the uptake of norepinephrine and
serotonin. Tramadol should be used with caution in patients with increased intracranial
pressure or head injury and patients with acute abdominal conditions.
USE IN PREGNANCY AND LACTATION
Safe use of Tramadol in pregnancy has not been established. Tramadol has been shown
to cross the placenta. There are no adequate and well-controlled studies in pregnant
women. Therefore, Tramadol should be used during pregnancy only if the potential
benefit justifies the risk to the foetus. Tramadol Hydrochloride should not be
administered during breast feeding as Tramadol and its metabolites have been detected
in breast milk.
USE IN CHILDREN
In children from the age of 1 year Tramadol Hydrochloride can be given in a dose of 1-2
mg/kg body weight.However,suppository (100 mg Tramadol Hydrochloride) should not
be administered in children and adolescents below the age of 14 years.
Tramadol Hydrochloride 100 mg SR Capsules have not been studied in children.
Therefore,safety and efficacy have not been established and the product should not be
used in children.
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Anadol SR 1pcs
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