Presentation:
ARISTOMOX 250 Capsule: Each capsule contains Amoxycillin Trihydrate BP 287.50 mg equivalent to Amoxycillin 250 mg.
ARISTOMOX 500 Capsule: Each capsule contains Amoxycillin Trihydrate BP 575 mg equivalent to Amoxycillin 500 mg.
ARISTOMOX Powder for Suspension: After reconstitution each 5 ml contains Amoxycillin Trihydrate BP 143.50 mg equivalent to Amoxycillin 125 mg.

Pharmacology:
Amoxycillin is a semi-synthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Amoxycillin is bactericidal against susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptides.

Indication:
ARISTOMOX is indicated in the following bacterial infections:Respiratory tract Infections, otitis media, enteric fever, urinary tract infections, gram-negative septicemia, gonorrhea, other surgical infections, prevention of infective endocarditis.

Dosage & Administration:
Usual oral dose: 250 to 500 mg every 8 hours.
Children up to 10 years: 125 to 250 mg every 8 hours.
Under 20 kg body weights: 20 to 40 mg/kg/day in divided doses every 8 hours.
Infants less than 3 months: Maximum dose should be 30 mg/kg/day in divided doses every 12 hours.

Special Dosage:
Uncomplicated gonorrhea: A single dose of 3 g with probenecid 1 g.
Dental abscess: 3 g repeated after 8 hours.
Uncomplicated acute urinary tract infections: 3 g repeated after 10-12 hours.
Prophylaxis of endocarditis: 2 or 3 g 1 hour before dental procedures under local or no anesthesia.
Severe or recurrent respiratory tract infections: 3 g twice daily.
Otitis media: children 3-10 years, 750 mg twice daily for 2 days.
H. pylori eradication: In combination with metronidazole or clarithromycin and a bismuth compound or an antisecretory drug usual doses of Amoxycillin are 750 mg or 1g twice daily or 500 mg three times daily.

Side effects:
Nausea, vomiting, diarrhoea, rashes (discontinue treatment), rarely antibiotic associated colitis.

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