Cilosta 100mg 10pcs

Description
Cilosta® : Each tablet contains Cilostazol INN 100 mg.
Pharmacology
Cilosta® is a preparation of Cilostazol which is a quinolinone derivative. The
mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III)
and suppress cAMP degradation with a resultant increase in cAMP in platelets and
blood vessels, leading to inhibition of platelet aggregation and vasodilation.
Indication
Cilosta® is indicated for the reduction of symptoms of intermittent claudication, as
indicated by an increased walking distance.
Dosage and Administration
The recommended dosage of Cilosta® is 100 mg bid, taken at least half an hour
before or two hours after breakfast and dinner. A dose of 50 mg bid should be
considered during coadministration of Fluconazole, Ketoconazole, Itraconazole,
Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline
and Diltiazem.
Contraindication
Cilostazol is contraindicated in patients with congestive heart failure of any severity.
Cilostazol is also contraindicated in patients with known or suspected
hypersensitivity to any of its components.
Side Effect
The most common side effects are headache, diarrhoea, vomiting, leg cramps,
rash etc. The less frequent side effects are anorexia and edema.
Use in Special Population
Pregnancy : There are no adequate and well controlled studies in pregnant women.
Lactation : Transfer of Cilostazol into milk has been reported in experimental
animals. Because of the potential risk to nursing infants, a decision should be
made to discontinue nursing or to discontinue Cilostazol. Paediatric use: The safety
and effectiveness of Cilostazol in paediatric patients have not been established.
Storage Condition
Store in a cool & dry place, protected from light and moisture.