Dilapress is a preparation of Carvedilol which is a cardiovascular drug
acts mainly as neurohormonal antagonist consisting of non-selective b
blockade, a1 blockade and antioxidant properties.
Dilapress is indicated for the treatment of essential hypertension. It can
be used alone or in combination with other antihypertensive agents,
especially thiazide type of diuretics.
Dilapress is also indicated for the treatment of mild to moderate heart
failure, to reduce the progression of disease, to reduce mortality and
Dilapress may be used in patients unable to tolerate an ACE inhibitor.
Dilapress may be used in patients who are not receiving digitalis,
hydralazine or nitrate therapy.
Dosage and Administration
In essential hypertension initially 12.5 mg once daily for 2 days is
recommended. Thereafter the recommended dose is 25 mg once daily.
If necessary the dose may be further increased at intervals of at least 2
weeks to maximum 50 mg daily in single or divided doses. In elderly
patients the initial dose of 12.5 mg daily may provide satisfactory
In heart failure, initially 3.125 mg twice daily may be given for 2 weeks,
dose may be increased at intervals of at least 2 weeks to 6.25 mg twice
daily, then to 12.5 mg twice daily, then to 25 mg twice daily. The dose
may be increased to highest dose tolerated, maximum 25 mg twice
daily in patients less than 85 kg body weight and 50 mg twice daily in
patients over 85 kg.
Side effects include dizziness, headache, fatigue, gastrointestinal
disturbances, postural hypotension, peripheral oedema, bradycardia, dry
mouth, dry eyes, eye irritation or disturbed vision, impotence,
disturbances of micturition, and influenza like symptoms. Rarely angina,
AV block, exacerbation of intermittent claudication or Raynaud’s
phenomenon, allergic skin reactions, nasal stuffiness, wheezing, depressed
mood, sleep disturbances, paresthesia, heart failure, changes in liver
enzymes, thrombocytopenia, leucopenia are reported.