Descriptions
Chemically, clonazepam is a benzodiazepine derivative. It exhibits several pharmacologic properties, which are characteristics of the benzodiazepine class of drugs. In human it is capable of suppressing the spike and wave discharge in absence seizure (petit mal) and decreasing the frequency, amplitude, duration and spread of discharge in minor motor seizure.
Indications
Tablet:
- Anxiety disorders (Generalized, Phobic & Panic disorders)
- Insomnia and sleep disturbances
- Labile arterial hypertension
- Peri and Post menopausal anxiety (Anxiety in middle aged women)
- Burning Mouth Syndrome
- Peri and Post menopausal anxiety (Anxiety in middle aged women)
- Postoperative anxiety disorder
- Post traumatic stress disorder
- Anxiety in cancer patient (palliative treatment)
- Tension Headache
- Restless legs syndrome (RLS) or Wittmaack–Ekbom syndrome
- Nocturnal myoclonus
- Tourette’s syndrome
- Bipolar affective disorder
- Resistant depression
- Drug-induced dyskinesia
- Choreiform movement
- Fulgurant pain
- Trigeminal neuralgia
- Epilespsy
- Injection:
- Epilepsy
- Status epilepticus
- Myoclonic seizure
- Typical and atypical absences (Lennox-Gastaut syndrome)
- Infantile spasm
- Tonic-clonic seizure
- Partial seizure
- Absence seizure
- Focal seizure
Dosage & Administration
Tablet:
Infants and children
Initial dose: 0.01 – 0.03 mg/kg/day. Up to 1 year: 0.25 mg daily in divided dose, not to exceed 0.05 mg/kg/days increase gradually to 0.5 – 1 mg.
Increment dose: not more than 0.25 – 0.5 mg 1 – 5 years: 0.25 mg daily in divided dose, at intervals of 3 days increase to 1 – 3 mg.
Maintenance dose: 0.1 – 0.2 mg/kg/day. 5 – 12 years: 0.5 mg daily in divided dose,
Dosing interval: b.i.d. / t.i.d. increase to 3 – 6 mg.
Adults and elderly
Initial dose: 1 mg daily in divided dose (Elderly 0.5 mg), not to exceed 1.5 mg/day
Increment dose: 0.5 – 1 mg at intervals of 3 days
Maintenance dose: 4 – 8 mg/day
Maximum dose: 20 mg/day should be administered with caution
Dosing interval: b.i.d. / t.i.d.
Initial dose should be low and increased gradually to a maintenance dose that controls seizure without toxic effects. During discontinuation, the dose should be tapered.
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