DESCRIPTION
Filmet is a sterile, pyrogen free, isotonic formulation for intravenous administration
in susceptible life threatening infections. Each 100ml solution contains
Metronidazole USP 500mg. Metronidazole is a nitroimidazole with antiprotozoal
and antibacterial actions. It is highly effective against Trichomonas vaginalis,
Entamoeba histolytica and Giardia lamblia. It has a bactericidal action against a
wide range of pathogenic anaerobic microorganisms particularly species of
Bacteroides, Fusobacteria, Clostridia, Eubacteria, Anaerobic Cocci a n d
Gardnerella vaginalis.
INDICATIONS
Filmet is indicated in the prophylaxis and treatment of infections in which anaerobic
bacteria have been identified or are suspected to be the causes. It is particularly
suited for patients who can not retain oral medication and for patients in whom
desired serum concentration have to be attained rapidly and reliably.
Filmet is indicated :
I . In the prevention of post operative infections due to anaerobic bacteria.
2. In the treatment of
a. Intra abdominal infections – appendicitis, cholecystitis, peritonitis, liver abscess
and post operative wound infections;
b. Gynaecological and obstetrical infections – puerperal sepsis, pelvic cellulitis,
pelvic peritonitis;
c. Respiratory infections – necrotizing pneumonia, empyema, lung abscess;
d. Central Nervous System infections – meningitis, brain abscess;
e. Miscellaneous infections – septicaemia, bacteremia, osteomyelitis, gas
gangrene.
ADVERSE EFFECTS
Serious adverse reactions occur very rarely with standard recommended regimens.
Unpleasant taste in the mouth, furred tongue, nausea, vomiting or other gastrointestinal
disturbances have been reported. Urticaria, skin rash, pruritus, angioedema and rarely
anaphylaxis have occurred. Drowsiness, dizziness, headache, ataxia and darkening of the
urine (due to metabolites) have been reported rarely. Peripheral neuropathy and/or transient
epileptiform seizures have occurred during prolonged or intensive treatment but in most cases
neuropathy disappears on cessation of therapy. A moderate, reversible leucopenia has been
reported in some patients.
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