Description:
Doxofylline is a type of enzyme inhibitor drugs that is used to treat Asthma and COPD. In animal
and human studies, it has shown similar efficacy to theophylline but with significantly less side
effects. Doxofylline belongs to category of enzyme inhibitor activity drugs. Specifically,
Doxofylline is a new generation long acting oral methylxanthine derivative. Methylxanthines are
phosphodiesterase inhibitors. Doxofylline also has antitussive and bronchodilator affects, and
acts as a phosphodiesterase inhibitor.
Indication:
Doxofylline is indicated for maintenance therapy in patients suffering with Asthma and Chronic
Obstructive Pulmonary Disease (COPD).
Dosage and administration:
Adults and children > 12 years of age: 400 mg 1 Tablet twice daily. The dosage may be
increased to t.i.d. according to the prescribing physician. The dosage (800 mg/ day) may be
decreased according to medical prescription in the
Very elderly patients with concomitant cardiovascular, hepatic, renal and gastric disease, to ½
tablet b.i.d.
Child (above 3 years of age): The recommended dosage of Doxofylline is 12 mg / kg daily,
divided into 2 doses. In case of unsatisfactory response it can be increased up to 18mg / kg daily
under medical supervision.
Doxofylline can be taken with or without food.
Side effects:
After xanthine administration, nausea, vomiting, epigastric pain, cephalalgia, irritability,
insomnia, tachycardia, extrasystole, tachypnea and occasionally, hyperglycemia and
albuminuria, may occur. If a potential oral overdose is established, the patient may present
with severe arrhythmias and seizure; these symptoms could be the 1st sign of an intoxication.
Adverse reactions may cause the withdrawal from treatment; a lower dose rechallenge may
start only after the advice of a physician.
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