Lesero 250mg/vial

Ceftazidime is indicated for Single infections, Mixed infections, Severe infections in general, Respiratory tract infections, Ear, nose and throat infections, Skin and soft tissue infections, Gastrointestinal, biliary and abdominal infections, Bone and joint infections, Dialysis: Infections associated with hemo and peritoneal dialysis and with continuous ambulatory peritoneal dialysis (CAPD).

Third generation Cephalosporins

Ceftazidime binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Prophylaxis of surgical infection in patients undergoing prostate surgery:

• Adult: 1 g at induction of anaesth repeated if necessary upon removal of catheter. It is given as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
• Elderly: >80 yr Max: 3 g daily.

Pseudomonal lung infections in cystic fibrosis:

• Adult: 100-150 mg/kg 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min. Max: 9 g daily.
• Child: <40 kg: 150 mg/kg daily in 3 divided doses. Max: 6 g daily.
• Elderly: >80 yr Max: 3 g daily

Bone and joint infections, Complicated intra-abdominal infections, Skin and skin structure infections, complicated:

• Adult: 1-2 g 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
• Child: <40 kg: 100-150 mg/kg daily in 3 divided doses. Max: 6 g daily.
• Elderly: >80 yr Max: 3 g daily.

Bacterial meningitis, Empiric therapy for febrile neutropenic patients, Nosocomial pneumonia:

• Adult: 2 g 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
• Child: <40 kg: 150 mg/kg daily in 3 divided doses. Max: 6 g daily.
• Elderly: >80 yr Max: 3 g daily.

Complicated urinary tract infections:

• Adult: 1-2 g 8-12 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
• Child: <40 kg: 100-150 mg/kg daily in 3 divided doses. Max: 6 g daily.
• Elderly: >80 yr Max: 3 g daily.

Increased nephrotoxicity has been reported following concomitant administration of Cephalosporins and aminoglycoside antibiotics.

Ceftazidime is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics.

The most common side-effects are local reactions following IV injection and allergic and gastrointestinal reactions. Hypersensitivity reactions are pruritus, rash, and fever. Angioedema and anaphylaxis have been reported very rarely. Gastrointestinal symptoms are diarrhea, nausea, vomiting, and abdominal pain. Central nervous system reactions included headache, dizziness, and paresthesia.

Pregnancy: No adequate and well controlled studies in pregnant women have been conducted with Ceftazidime. Because animal reproduction studies are not always predictive of human response this drug should be used during pregnancy only if clearly needed.Lactation: Ceftazidime is excreted in human milk in low concentrations. Because many drugs are excreted in human milk and because safety of the component of the injections in nursing infants has not been established, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.