Indications and Usage
Nitrosol® Aerosol is indicated for acute relief of an attack or prophylaxis of angina pectoris due to coronary artery disease.
Dosage and Administration
At the onset of an attack, one or two metered sprays should be administered under the tongue. No more than three metered sprays are recommended within a 15-minute period. If the chest pain persists, prompt medical attention is recommended. Nitrosol® Aerosol may be used prophylactically five to ten minutes prior to engaging in activities which might precipitate an acute attack.
Contraindications
Nitroglycerin is contraindicated in patients who are allergic to it. Nitrosol® Aerosol is contraindicated in patients taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), Hypotensive Shock, Narrowangle Glucoma, Severe anaemia, Cerebral haemorrhage and brain trauma.
Side Effects
Transitional, mild burning sensation in the mouth. Pulsation in the head, facial flush, headache, dizziness, palpitation, sensation of heat, nausea, sweating. Mainly at overdosage, methemoglobinemia and cyanosis may occur.
Precautions
Severe hypotension, particularly with upright posture, may occur even with small doses of nitroglycerin. The drug, therefore, should be used with caution in subjects who may have volume depletion from diuretic therapy or in patients who have low systolic blood pressure (e.g., below 90 mm Hg). Paradoxical bradycardia and increased angina pectoris may accompany nitroglycerin-induced hypotension. Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy.
PREGNANCY:
Pregnancy Category C. NURSING MOTHERS: It is not known whether nitroglycerin is excreted in human milk. PEDIATRIC USE: Safety and effectiveness of nitroglycerin in pediatric patients have not been established.
Drug Interactions
It should be applied with precaution together with antihypertensive, tricyclic antidepressants (hypotension is enhanced)
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