Omeprazole offers significant therapeutic gains in the treatment of acid related diseases. Healing rates are high in duodenal ulcer, gastric ulcer and erosive reflux oesophagitis; acid production is controlled effectively in Zollinger-Ellison Syndrome and symptom relief is prompt and sustained in all indications. Less clear-cut indications where benefit might be expected but where data are limited include:
- Prevention of stress ulceration
- Prevention of the acid aspiration syndrome
- Treatment of upper gastro-intestinal bleeding
NOTE: In comparative studies, Omeprazole has been found to produce faster symptom relief and higher healing rates in a greater percentage of patients than either Cimetidine or Ranitidine, confirming the ‘therapeutic gains’ achievable with Omeprazole over existing therapies.
Pregnancy: There are no adequate and well-controlled studies on the use of Omeprazole in pregnant women. Therapeutic doses during pregnancy are unlikely to pose a substantial teratogenic risk. Omeprazole should be used during pregnancy only if the potential benefit to pregnant women justifies the potential risk to the fetus.
Lactation: Omeprazole is excreted in human milk. Thus, a decision should be taken to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.