Doxophylline is a novel bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7.
Doxophylline selectively inhibits phosphodiesterase 4 thereby relaxes bronchial smooth muscle. However, differently from Theophylline, Doxophylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxophylline is reported to inhibit platelet activating factor (PAF) and generation of leukotriene production.
Dosage & Administration
Adult: 400 mg daily in the evening. However, in certain cases, 400 mg twice daily is recommended on the basis of the clinical response. Doses as high as 1200 mg/day (400 mg 3 times daily) may also be prescribed. In elderly patients with concomitant cardiovascular, hepatic and renal diseases recommended dosage should be 200 mg twice daily.
Children (above 6 years of age): The recommended dosage of Doxophylline is 6 mg/kg twice daily. The dose may be increased up to 18 mg/kg daily on the basis of clinical response.
Dosage Type: 6 mg/kg b.i.d
Weight of the Child: 10 kg > Dosage: 3 ml
Weight of the Child: 15 kg > Dosage: 4.5 ml
Weight of the Child: 20 kg > Dosage: 6 ml
Weight of the Child: 25 kg > Dosage: 7.5 ml
Weight of the Child: 30 kg > Dosage: 9 ml
Weight of the Child: 35 kg > Dosage: 10.5 ml
Weight of the Child: 40 kg > Dosage: 12 ml
Pregnancy & Lactation
Use in nursing mothers: Doxophylline is contraindicated in nursing mothers.