Indications
Therapeutic Class
Pharmacology
The plasma elimination half life is about 20 hours. The majority of Secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours). The pharmacokinetic profile of Secnidazole gives it the longest half-life of all the second generation nitroimidazoles, ensuring 72-hour therapeutic blood levels from a 2 gm single dose.
Dosage & Administration
Secnidazole Tablet:
Amoebiasis:
Acute intestinal amoebiasis:
- Adults: 2 gm single dose (2×1000 mg tablet), taken preferably just before meal.
- Children: 30 mg/kg single dose, taken preferably just before meal.
Asymptomatic amoebiasis (minute & cystic form):
- Adults: 2 gm once daily (2×1000 mg tablet) for only 3 days, taken preferably just before meal.
- Children: 30 mg/kg once daily for only 3 days, taken preferably just before meal.
Hepatic amoebiasis :
- Adults: 1.50 gm/day, in a single or divided dose, just before meal for 5 days.
- Children: 30 mg/kg/day, in a single or divided dose, just before meal for 5 days.
N.B.: Evacuation of pus must be performed simultaneously with Secnidazole treatment at the suppurative stage of hepatic amoebiasis.
Giardiasis :
- Adults: 2 gm single dose (2×1000 mg tablet), taken preferably just before meal.
- Children: 35-50 mg/kg single dose, taken preferably just before meal.
Trichomoniasis :
- Adults: 2 gm single dose (2×1000 mg tablet), taken preferably just before meal.
- Children: 30 mg/kg single dose, taken preferably just before meal. The partner should also receive the same treatment concomitantly.
Secnidazole Suspension:
Suspension should be administered orally. The dosage schedule of Secnidazole suspension is mentioned below:
- Children of 10 to 15 kg body weight: 1 bottle of Secnidazole 500 mg suspension.
- Children of 16 to 25 kg body weight: 1½ bottle of Secnidazole 500 mg suspension.
- Children of 26 kg or more body weight: 2 bottles of Secnidazole 500 mg suspension.
Interaction
Contraindications
Side Effects
Occasional side-effects: Urticaria, moderate leukopenia which is reversible on treatment discontinuation.
Rare side-effects: Vertigo, ataxia and motor incoordination, paresthesia, and peripheral neuropathy. With secnidazole, gastrointestinal disorders e.g. nausea, vomiting, epigastric pain, etc. have been reported in very rare cases.
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