Capsule/Suspension/DS Suspension/Paediatric Drops
Tycil contains Amoxicillin (as trihydrate BP) which is chemically D(-)-µamino-p-hydroxybenzylpenicillin.
It is a broad-spectrum, bactericidal
antibiotic similar to Ampicillin in the spectrum of activity but is better
absorbed when taken orally and produces a higher blood level.
Tycil is indicated in the following bacterial infections-
¨ Infections of the respiratory tract and ear : Laryngitis, pharyngitis, tonsillitis,
sinusitis, chronic and acute bronchitis, pneumonia and otitis media.
¨ Infections of the biliary and Gastrointestinal tract : Salmonellosis, including
the carrier stage, cholecystitis, peritonitis.
¨ Infections of the genito-urinary tract : Nephritis, pyelitis, pyelonephritis,
cystitis, urethritis and gonorrhoea, bacteriuria in pregnancy.
gynaecological infections including puerperal sepsis and septic
¨ Skin and soft tissue infections : Boils, carbuncles, cellulitis.
¨ Prophylaxis of endocarditis : Tycil may be used for the prevention of
developing bacterial endocarditis, associated with procedures such as
¨ Others : Pre and post-operative prophylaxis and treatment of infections,
Dosage and Administration
Adult dosage (including elderly patients) :
¨ Standard dosage : It is 250 mg three times daily, increasing up to 500 mg
three times daily for more severe infections.
¨ Severe or recurrent infection of the respiratory tract : A dosage of 3 g
twice daily is recommended in appropriate cases. (Maximum
recommended oral dosage is 6 g daily in divided doses).
¨ Uncomplicated acute urinary tract infection : A single dose of 3 g.
¨ Gonorrhoea : A single dose of 3 g, often with 1 g probenecid in the
treatment of uncomplicated gonorrhoea in areas where the pathogen is
sensitive to Amoxicillin.
¨ Prophylaxis of endocarditis in susceptible patients : A single dose of
3 g about 1 hour before procedures such as dental extraction.
Children dosage :
¨ Children up to 10 years of age may be given the equivalent of 125 to
250 mg three times daily.
¨ Children weighing 20 kg or more should be given doses according to
the recommended dosage for adults.
¨ Children under 20 kg body weight a dose of 20 to 40 mg per kg daily
has been suggested.
¨ In prophylaxis of endocarditis, children may be given half of the adult
dose, i.e., 1.5 g about 1 hour before procedures such as dental
Tycil is contraindicated in patients with known hypersensitivity to
In presence of gastrointestinal diseases such as diarrhoea and vomiting,
absorption of oral preparation is doubtful. Like all broad-spectrum
antibiotics, superinfection may occur in association with Amoxicillin. In
such cases treatment with Amoxicillin should be discontinued and
appropriate therapy to combat superinfection should be instituted.
Side effects, as with other penicillins, are rare and usually of mild and
transient in nature. Skin rashes may appear to some patients. This must be
reported to the physician and treatment should be discontinued.
Gastrointestinal complaints such as diarrhoea have occasionally been
observed. These usually subside on continuation of therapy. Incidence of
persistent diarrhoea should be reported to the physician.
Tycil® 500 Capsule : Box containing 5 blister strips of 10 capsules, each
capsule contains Amoxicillin Trihydrate BP equivalent to 500 mg
Tycil® 250 Capsule : Box containing 10 blister strips of 10 capsules, each
capsule contains Amoxicillin Trihydrate BP equivalent to 250 mg
Tycil® Suspension : Dry powder in amber glass bottle for reconstitution
into 100 ml suspension. After reconstitution, each 5 ml contains
Amoxicillin Trihydrate BP equivalent to 125 mg Amoxicillin.
Tycil® DS Suspension : Dry powder in amber glass bottle for
reconstitution into 100 ml suspension. After reconstitution, each 5 ml
contains Amoxicillin Trihydrate BP equivalent to 250 mg Amoxicillin.
Tycil® Paediatric Drops : Dry powder in amber glass bottle for
reconstitution into 15 ml suspension. After reconstitution, each 1.25 ml
contains Amoxicillin Trihydrate BP equivalent to 125 mg Amoxicillin.