Xenovate 10gm

Indications
Clobetasol Propionate is indicated in:
Initial control of all forms of hyperacute eczema in all age groups
Chronic hyperkeratotic eczema of the hands and feet and patches of chronic lichen simplex
Chronic hyperkeratotic psoriasis of any area of the body
Severe acute photosensitivity
Hypertrophic lichen planus
Localized bullous disorders
Keloid scarring
Pretibial myxoedema
Vitiligo
Suppression of reaction after cryotherapy
Scalp Solution is indicated in the topical therapy of recalcitrant corticosteroid-responsive dermatoses of the scalp, including recalcitrant cases of psoriasis and seborrheic dermatitis.
Therapeutic Class
Clobetasol / Clobetasone & Combined Preparations
Pharmacology
Clobetasol has both local anti-inflammatory and immunosuppressive activity. The drug blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin. Clobetasol also reduces the number of human leukocyte antigen & also inhibits phospholipase A2 activity via formation of lipocortin. Clobetasol reduces the formation of prostaglandins and leucotrienes in the local tissues.
Dosage & Administration
Topical cream/ ointment: Clobetasol should be applied with gentle rubbing to the affected skin areas twice daily. Dosage should not normally exceed 50 gm/ week and the duration of a course should not be more than 4 weeks. The potency can further enhanced by the use of occlusive dressing.

Scalp Solution: Apply required quantity of spray of Clobetasol Scalp Solution once or twice daily to the affected areas of the scalp and gently rub in. The total dose applied should not exceed 50 ml weekly. If necessary, Clobetasol Scalp Solution may be massaged into the scalp using the tips of the fingers. Therapy should be discontinued if no response is noted after one week or as soon as the lesion heals. It is advisable to use Clobetasol Scalp Solution for brief periods only.
Interaction
No hazardous interactions have been reported with use of Clobetasol Propionate.
Contraindications
Contraindicated in Cutaneous infections such as impetigo, tinea corporis and herpes simplex, Infestations such as scabies, Acne vulgaris, Hypersensitivity, Rosacea, Gravitational ulceration, Perioral dermatitis, Children under 1 year
Side Effects
Generally this preparation is well tolerated. However, few side effects after prolonged and intensive treatment may cause local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels, particularly when occlusive dressings are used, or when skin folds are involved.