Indications
Pharmacology
Docetaxel was found to be cytotoxic in vitro against various murine and human tumour cell lines and against freshly excised human tumour cells in clonogenic assays. Docetaxel achieves high intracellular concentrations with a long cell residence time. In addition, docetaxel was found to be active on some but not all cell lines over expressing the p-glycoprotein which is encoded by the multidrug resistance gene. In vivo, docetaxel is schedule-independent and has a broad spectrum of experimental antitumour activity against advanced murine and human grafted tumours.
Dosage & Administration
Breast cancer:
- In the adjuvant treatment of operable node +ve:Â 75 mg/m2Â administered 1 hr after doxorubicin 50 mg/m2Â & cyclophosphamide 500 mg/m2Â every 3 wk for 6 cycles.
- For the treatment of patients with locally advanced or metastatic breast cancer:Â 100 mg/m2Â in monotherapy.
- In the 1st-line treatment combination therapy:Â 75 mg/m2Â with doxorubicin (50 mg/m2).
- In combination with trastuzumab:Â 100 mg/m2Â every 3 wk, administered wkly.
- In combination with capecitabine:Â 75 mg/m2Â every 3 wk, combined with capecitabine at 1250 mg/m2Â twice daily (within 30 min after a meal) for 2 wk followed by a 1-wk rest period.
Non-small cell lung cancer:
- In chemotherapy-naive patients treated for non-small cell lung cancer:Â 75 mg/m2Â immediately followed by cisplatin 75 mg/m2Â over 30-60 min.
- For treatment after failure of prior platinum-based chemotherapy:Â 75 mg/m2Â as a single agent.
Prostate cancer:Â 75 mg/m2. Prednisone or prednisolone 5 mg orally twice daily is administered continuously
Gastric adenocarcinoma:Â 75 mg/m2Â as 1-hr infusion, followed by cisplatin 75 mg/m2, as 1-3-hr infusion (both on day 1 only), followed by 5-fluorouracil 750 mg/m2/day given as 24-hr continuous infusion for 5 days, starting at the end of the cisplatin infusion.
Head & neck cancer:Â For the induction treatment of inoperable locally advanced squamous cell carcinoma of the head & neck: 75 mg/m2Â as 1-hr infusion followed by cisplatin 75 mg/m2Â over 1 hr on day 1, followed by 5-fluorouracil as a continuous infusion at 750 mg/m2Â per day for 5 days. Administered every 3 wk for 4 cycles. Following chemotherapy, patients should receive radiotherapy.
Ovarian cancer:Â 75-100 mg/m2Â administered as 1-hr infusion every 3 wk.
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