Amdocal Plus 25 10pcs

Description

Amdocal Plus consists of Amlodipine Besylate and Atenolol. Amlodipine Besylate is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle
cells. Amlodipine acts directly on vessels to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Atenolol is (2- hydroxy-3-isopropyl-aminopropoxy) phenylacetamide, a selective b1 blocker. Beta blockers are the b adrenoceptor blocking drugs, blocking the effects of adrenergic stimulation mediated through these receptors. It is devoid of intrinsic sympathomimetic activity and it decreases heart rate and cardiac output. Further, Atenolol decreases plasma renin activity.

Indications

· Hypertension not controlled by monotherapy
· Angina pectoris & hypertension co-existing diseases
· Post MI patients
· Refractory angina pectoris where nitrate therapy has failed

Dosage and Administration
The recommended dosage is one tablet daily of Amdocal Plus 50(Amlodipine 5 mg + Atenolol 50 mg) or Amdocal Plus 25 (Amlodipine 5 mg + Atenolol 25 mg). Depending upon the therapeutic response,titration of the dosage is recommended. In elderly patients, it is advisable to initiate the therapy with 1/2 tablet of fixed dose combination of Amlodipine & Atenolol (i.e. 2.5 mg of Amlodipine & 25 mg Atenolol).