Indication
Acyclovir IV for Infusion is indicated for the treatment of
• Herpes Simplex infections in immunocompromised patients
• Initial and recurrent mucosal and cutaneous Herpes Simplex (HSV-1 and HSV-2) infections in immunocompromised patients
• Severe initial clinical episodes of herpes genitalis in immunocompetent patients
• Herpes Simplex encephalitis
• Neonatal herpes simplex virus infections and varicella-zoster (shingles) infections in immunocompromised patients.
Dosage & Administration
Method of Preparation:
The required dose of Acyclovir IV for Infusion should be administered by slow intravenous infusion over a one-hour period. Acyclovir 250 mg IV for Infusion should be reconstituted in 10 ml of Water for Injections BP or Sodium Chloride Injection BP (0.9% w/v) and Acyclovir 500 mg IV for Infusion should be reconstituted in 10 ml of Water for Injections BP or Sodium Chloride Injection BP (0.9% w/v) to provide a solution containing 25/50 mg acyclovir per ml. From the calculated dose, determine the appropriate number of vials to be used. Shake the vial gently until the contents of the vial have dissolved completely. After reconstitution Acyclovir IV for Infusion may be administered by a controlled rate infusion pump. Alternatively, the reconstituted solution may be further diluted to give an acyclovir concentration of not greater than 5 mg/ml (0.5% w/v) for administration by infusion:- Add the required volume of reconstituted solution to Sodium Chloride 0.9% w/v infusion solution and shake well to ensure adequate mixing occurs.
• For children and neonates, where it is advisable to keep the volume of infusion fluid to a minimum, it is recommended that dilution is on the basis of 4 ml reconstituted solution of Acyvir 250 mg Injection or 2 ml reconstituted solution of Acyvir 500 mg Injection (100 mg Acyclovir) added to 20 ml of infusion fluid.
• For adults, it is recommended that infusion bags containing 100 ml of infusion fluid are used, even when this would give an Acyclovir concentration substantially below 0.5% w/v. Thus one 100 ml infusion bag may be used for any dose between 250 mg and 500 mg Acyclovir but a second bag must be used for doses between 500 mg and 1000 mg. When diluted in accordance with the recommended schedules, Acyclovir IV for Infusion is stable for up to 12 hours at room temperature. Reconstituted or diluted solution should not be refrigerated.
Side effects
Most common side effects are headache, nausea, diarrhea, rash and phlebitis.
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