Apulset 4mg 10pcs

Tablet & Oral Solution:

For adults:
Prevention of nausea & vomiting associated with chemotherapy: Highly emetogenic chemotherapy: 24 mg once 30 minutes before start of single-day chemotherapy. Moderately emetogenic chemotherapy: 8 mg every 8 hours for 2 doses beginning 30 minutes before chemotherapy, then 8 mg every 12 hours for 1-2 days after chemotherapy completed.
Prevention of nausea & vomiting associated with radiotherapy: Total body irradiation: 8 mg 1-2 hours before each fraction of radiotherapy administered each day. Single high-dose fraction radiotherapy to abdomen: 8 mg 1-2 hours before radiotherapy, then 8 mg every 8 hours after 1st dose for 1-2 days after radiation completed. Daily fractionated radiotherapy to abdomen: 8 mg 1-2 hours before radiotherapy, then 8 mg every 8 hours after 1st dose for each day of radiotherapy.
Prevention of post-operative nausea & vomiting: 16 mg 1 hour before induction of anesthesia.

For children:
Prevention of nausea & vomiting associated with highly emetogenic chemotherapy, radiotherapy, or <4 yrs of age: not recommended. Prevention of nausea & vomiting associated with moderately emetogenic chemotherapy (4-11 yrs): 4 mg every 4 hours for 3 doses beginning 30 minutes before chemotherapy, then 4 mg every 8 hours for 1-2 days after chemotherapy completed.

Injection:
For adults:
Prevention of nausea & vomiting associated with chemotherapy: Infuse over 15 minutes. 0.15 mg/kg (max 16 mg/dose) IV every 4 hours for 3 doses beginning 30 minutes before chemotherapy.
Prevention of post-operative nausea & vomiting: Infuse in not less than 30 seconds, preferably over 2-5 minutes: 4 mg IV as single dose immediately before induction of anesthesia; or shortly post-operative if nausea or vomiting occurs. Or, may use 4 mg IM undiluted as a single injection.
For children:
Prevention of nausea & vomiting associated with chemotherapy: Infuse over 15 minutes. 6 months-18 yrs: 0.15 mg/kg (max 16 mg/dose) IV for 3 doses every 4 hours beginning 30 minutes before chemotherapy.
Prevention of post-operative nausea & vomiting: Infuse in not less than 30 seconds, preferably over 2-5 minutes. 1 month-12 yrs (<40 kg): 0.1 mg/kg; 40 kg: 4 mg. Give IV as single dose immediately before induction of anesthesia; or shortly post-op if nausea or vomiting occurs.

Dosage adjustment for patients with impaired hepatic function:
The dosage recommendation is the same as for the general population. For severe hepatic dysfunction a total daily dose of 8 mg should not be exceeded.

Side effects