Presentation:
Asmalin HFA Inhaler: Each puff delivers Salbutamol Sulphate BP equivalent to Salbutamol 100 µg.
Salbutamol is a selective beta2-adrenoceptor agonist. At therapeutic doses, it acts on the beta2-adrenoceptors of bronchial smooth muscle, with little or no action on the ß1-adrenoceptors of cardiac muscle. Salbutamol provides short acting (4-6 hours) bronchodilatation with a fast onset (within 5 minutes) in reversible airways obstruction. It also has an anti-inflammatory effect on mast cells causing inhibition of release of bronchoconstrictor mediators including histamine, neutrophil chemotactive factor (NCF) and prostaglandin D2.
Indication:
Bronchospasm: Asmalin HFA Inhaler is indicated for the treatment or prevention of bronchospasm in bronchial asthma and for the treatment of reversible airways obstruction associated with bronchitis and emphysema.
Exercise-Induced Bronchospasm : Asmalin HFA Inhaler may be used to relieve attacks of acute dyspnoea and may also be taken prophylactically before exertion or to prevent exercise-induced asthma.
Dosage and Administration:
Administer Asmalin HFA Inhaler by oral inhalation only. Shake Asmalin HFA Inhaler well before each spray.
For relief of acute episodes of bronchospasm:
Adults: 1 or 2 puffs as necessary. The maximum dose is up to 8 puffs in 24 hours.
Children: Half the adult dose.
To prevent allergen- or exercise-induced bronchospasm:
Adults: 2 puffs 15 minutes prior to exercise or exposure to allergen.
The maximum dose is 2 puffs, up to 4 times a day.
Children: Half the adult dose.
Chronic therapy:
Adults: Up to 200 µg (2 puffs) four times daily
Children: Up to 200 µg (2 puffs) four times daily
Side effect:
Salbutamol is generally well tolerated. Few side effects have been observed during inhalation. There are tremor, anxiety, muscle cramps, headache, palpitation, a compensatory small increase in heart rate, cardiac arrhythmias (including atrial fibrillation, supraventricular tachycardia and extrasystoles), tachycardia may occur in some patients. Mouth and throat irritation may occur with inhaled salbutamol.
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