Indications
Axon is indicated for the treatment of the following major infections:
1. Renal and urinary tract infections
2. Lower respiratory tract infections, particularly pneumonia
3. Gonococcal infections
4. Skin,soft tissue, bone and joint infections
5. Bacterial meningitis
6. Serious bacterial infections e.g. septicemia
7. ENT infections
8. Infections in cancer patients
9. Prevention of postoperative infections
10. Perioperative prophylaxis of infections associated with surgery
11. Typhoid fever.
Dosage & Administration
Adult: By deep intramuscular injection, or by intravenous injection over at least 2-4 minutes, or by intravenous infusion, 1 g daily; 2-4 g daily in severe infections; intramuscular doses over 1 g divided between more than one site. Neonate: By intravenous infusion over 60 minutes, 20-50 mg/kg daily (max.50 mg/kg daily). Infant and child under 50 kg: by deep intramuscular injection or by intravenous injection over 2-4 minutes or by intravenous infusion, 20-50 mg/kg daily; up to 80 mg/kg daily in severe infections; doses of 50 mg/kg and over by intravenous infusion only; 50 kg and over, adult dose.
Uncomplicated gonorrhea: by deep intramuscular injection, 250 mg as a single dose. Surgical prophylaxis: by deep intramuscular injection or by intravenous injection over at least 2-4 minutes, 1 g at induction, Colorectal surgery: by deep intramuscular injection or by intravenous injection over at least 2-4 minutes or by intravenous infusion, 2 g at induction; intramuscular doses over 1 g divided between more than one site.
Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.
Preparation of Solutions for Intramuscular/intravenous Injections:
For intramuscular injection: 250 mg or 500 mg Axon should be dissolved in 2 ml of 1% Lidocaine Injection USP or 1 g Axon in 3.5 ml of 1% Lidocaine Injection USP. For intravenous injection: 250 mg or 500 mg Axon should be dissolved in 5 ml of Water for Injection BP or 1 g Axon in 10 ml of Water for Injection BP or 2 g Axon in 20 ml of Water for Injection BP. The injection should be administered over 2-4 minutes, directly into the vein or via the tubing of an intravenous infusion. The use of freshly reconstituted solution is recommended. However, it maintains potency for at least 6 hours at room temperature or 24 hours at 5°C.
Side Effects
Ceftriaxone is generally well tolerated. A few side effects such as gastro-intestinal effects including diarrhoea, nausea and vomiting, stomatitis & glossitis; cutaneous reactions including rash, pruritus, urticaria, oedema & erythema multiforme; hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia; hepatic reactions including elevations of SGOT or SGPT, bilirubinemia; CNS reactions including headache, hyperactivity, nervousness, sleep disturbances, confusion, hypertonia and dizziness were reported. Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes.
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
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