AZ 20ml

Indications

AZ is indicated in lower respiratory tract infections including bronchitis and pneumonia, otitis media and in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, skin and soft tissue infections, mild to moderate typhoid due to multiple-antibacterial resistant organisms, cholera in children & adult and sexually transmitted diseases both in men and women. Azithromycin is also indicated for the treatment of uncomplicated genital infections due to Chlamydia trachomatis and urethritis and cervicitis due to Chlamydia trachomatis and Neisseria gonorrhoea.

Dosage & Administration

AZ Tablet & Taste Masked Powder for Suspension may be taken with or without food but AZ Capsule should be taken at least 1 hour before or 2 hours after food.
Adult : For sexually transmitted disease caused by Chlamydia trachomatis the dose is 1 g as a single dose. For all other indications, the total dose is 1.5 g which should be given as 500 mg daily for 3 days or initially, 500 mg as a single doses followed by a 250 mg single daily dose for the next 4 days. For typhoid fever, the dose is 500 mg once daily for 14 days.
Elderly : Normal adult dose is recommended.
Children > 6 months : The usual dose is 10 mg/kg body weight as a single daily dose for three days: for body weight 15-25 kg, 200 mg or 5 ml/day for 3 days: body weight 26-35 kg, 300 mg or 7.5 ml/day for 3 days: body weight 36-45 kg, 400 mg or 10 ml/day for 3 days. For typhoid fever 10 mg/kg body weight once daily for 7 days or 20 mg/kg body weight once daily for 5 days.
Children < 6 months : Not recommended.

Side Effects

AZ is well tolerated with a low incidence of side effects. Majority of the side effects are mild to moderate in nature and of gastro-intestinal in origin with nausea, abdominal discomfort, vomiting, flatulence and diarrhoea. Allergic reactions such as rash have occurred and there have also been rare reports of serious hypersensitivity reactions. Reversible elevations in liver transaminase have been seen with a frequency similar to the comparative macrolides and penicillins used in clinical trials.

Contraindications

AZ is contraindicated in patients with known hypersensitivity to Azithromycin, erythromycin or any of the macrolide antibiotics.