COMPOSITION
Camlodin® 5 : Each tablet contains Amlodipine Besilate BP equivalent to 5 mg Amlodipine.
INDICATIONS
Hypertension
Camlodin® is indicated for the frst line treatment of hypertension. It may be used alone or in combination
with other antihypertensive agents.
Chronic Stable Angina
Camlodin® is indicated for the treatment of stable angina.
Camlodin® may be used alone or in combination with other antianginal agents.
Vasospastic Angina
Camlodin® is indicated for the treatment of conrmed or suspected vasospastic angina.
Camlodin® may be used as monotherapy or in combination with other antianginal drugs.
PHARMACOLOGY
Amlodipine is a calcium antagonist of the dihydropyridine group & inhibits the transmembrane inux of
calcium ion into cardiac & smooth muscle. It is used for the treatment of hypertension and angina pectoris.
DOSAGE AND ADMINISTRATION
The usual initial antihypertensive oral dose of Camlodin® is 5 mg once daily with a maximum dose of 10
mg once daily. Small, fragile or elderly individuals or patients with hepatic insuciency may be started on
2.5 mg once daily dose and this dose may be used when adding Camlodin® to other antihypertensive
therapy. Dosage should be adjusted according to each patient’s need.
The recommended dose for stable or vasospastic chronic angina is 5-10 mg, with the lower dose suggested
in the elderly and in patients with hepatic insuciency.
CONTRAINDICATION
Camlodin® is contraindicated in patients with known hypersensitivity to dihydropyridine
(e.g. nifedipine, nicardipine, isradipine etc.)
PRECAUTIONS
Generally since the vasodilatation induced by Amlodipine is gradual in onset, acute hypotension has rarely been reported after oral administration of Amlodipine. Nonetheless caution should be exercised when administering Amlodipine with any other peripheral vasodilator particularly in patients with severe aortic stenosis.
Use in patients with congestive heart failure: Although haemodynamic studies and a controlled trial in
class-II-III heart failure patients have shown that Amlodipine did not lead to clinical deterioration as
measured by exercise tolerance, left ventricular ejection fraction and clinical symptomatology in general,
all calcium channel blockers should be used with caution in patients with heart failure.
Beta-blocker withdrawal: Amlodipine is not a Beta-blocker and therefore gives no protection against the
danger of abrupt Beta-blocker withdrawal; any such withdrawal should be gradual reduction of the doses of Beta-blocker.
Patients with hepatic failure: Since Amlodipine is extensively metabolised by the liver, in patients with
impaired hepatic function caution should be exercised, when administering Amlodipine to patients with
hepatic impairment.
DRUG INTERACTIONS
Digoxin: Absence of any interaction between Amlodipine and Digoxin in healthy volunteers has been
documented in a controlled clinical study.
Warfarin: An unpublished study in healthy volunteers indicates that Amlodipine did not signicantly alter the effect of Warfarin on prothrombin time.
Cimetidine: An unpublished clinical study indicated no interaction between Amlodipine & Cimetidine in
healthy volunteers.
Food: Food does not alter the rate or extent of absorption of Amlodipine.
SIDE EFFECTS
It is well tolerated. Headache, edema, fatigue, nausea, ushing, dizziness, gum hyperplasia, erythema
multiforme are reported.
OVERDOSAGE
Overdose might be expected to cause excessive peripheral vasodilation with marked hypotension &
possibly a relex tachycardia. In human, experience with intentional overdosage of Amlodipine is limited. If massive overdosage occurs, active cardiac and respiratory monitoring should be instituted. Frequent
blood pressure measurements are essential.
STORAGE
Store in a dry place, at below 300 C. Protect from light and moisture. Keep out of the reach of children.
HOW SUPPLIED
Camlodin® 5 : Each box contains 60 tablets in blister pack.
Camlodin 5mg 15pcs
৳ 75
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