Indications :
J Healing of erosive reflux oesophagitis.
J Zollinger – Ellison syndrome.
J For the treatment of gastric ulcers.
J For the treatment of duodenal ulcers.
Dosage & administration : Erosive Reflux
Oesophagitis : The recommended dosage
is one 20mg Cosec capsule once daily
before meal, given for 4 weeks. For those
patients not fully healed after the initial
course, healing usually occurs during a
further 4 weeks treatment.
Patients With Reflux Oesophagitis
Refractory to Other Therapy :
The recommended dosage is 40mg Cosec
once daily before meal. Healing usually
occurs within 8 weeks.
Duodenal Ulcer : The usual dose is one
20mg Cosec capsule once daily, before
meal for 4 weeks. In severe cases the dose
may be increased to 40mg Cosec capsule
once daily before meal.
Gastric Ulcer : The usual dose is one 20mg
Cosec capsule once daily before meal for 8
weeks. In severe cases, the dose may be
increased to 40mg Cosec capsule once
daily. Long-term maintenance treatment with
Cosec capsule is not recommended.
Zollinger-Ellison Syndrome : The
recommended initial dosage is 60mg (40mg
+ 20mg) once daily before meal. The
dosage should be adjusted individually and
treatment continued as long as clinically
indicated. More than 90% of patients with
severe disease and inadequate response to
other therapies have been effectively
controlled on doses of 20mg – 120mg daily.
With doses above 80mg daily, the dose
should be divided and given twice daily.
Elderly : Dose adjustment is not required in
the elderly.
Children : There is no experience of the use
of Cosec capsule in children.
Impaired Renal or Hepatic Function :
Dose adjustment is not required in patients
with impaired renal or hepatic function.
Patients with severe liver disease should not
require more than one 20mg Cosec daily or
as directed by a registered physician.
Contraindication : Cosec delayed release
capsules are contraindicated in patients with
known hypersensitivity to any component of
the formulation.
Use in pregnancy and lactation :
Omeprazole has been assigned to
pregnancy category C by the FDA.
Drug interaction : Omeprazole can prolong
the elimination of diazepam, warfarin and
phenytoin, drugs that are metabolized by
oxidation in the liver.
Side effects : Cosec delayed release
capsules are well tolerated. Nausea,
headache, diarrhea, constipation, flatulence
and skin rashes may occur rarely
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Cosec 20mg 1pcs
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