Composition:
Dopadon Tablet: Each tablet contains Domperidone BP (as Domperidone Maleate BP) 10 mg. Dopadon
Suspension: Each 5 ml suspension contains Domperidone BP 5 mg.
Description:
Dopadon blocks the receptor binding activity of Dopamine. Though all of the Dopaminergic receptors
(D1, D2, D3, D4 & D5) are present in the brain but Dopadon blocks only the chemoreceptor trigger zone
and stomach. Dopadon has an action to the gastrointestinal motility. Dopadon does not readily
enters the brain that ‘s the reason Dopadon has insignificant effects (psychotropic and neuroloic) on the
dopaminergic receptors of Brain. Dopadon accelerates transit through the small intestine, facilitates
gastric emptying, enhances antral and duodenal peristalsis and regulates contraction of the pylrus.
Dopadon increases lower esophageal spinchter pressure and esophageal peristalsis and prevents the
regurgitation of gastric content, thus prevents the rumination.
Indications:
1) Stimulation of Gastrointestinal mobility
a. Esophageal reflux, Reflux esophagitis and gastritis
b. Diabetic gastroparesis.
c. Heartbum with or without regurgitations of gastric contents in the mouth.
d. Non-ulcer dyspepsia
e. Functional dyspepsia
f. Speeding barium transit in ”follow-through” radiological studies.
g. Acute nausea and vomiting.
2) Prevention and Symptomatic relief of acute nausea and vomiting in the adults
from any cause but specifically :
a. Cytotoxic therapy
b. Nausea and Vomiting associated withe L-dopa and bromocriptine treatment
for parkinsonian patients.
c. Radiological therapy.
3) Stimulate lactation for lactating mothers
Dosage and Administration:
Dopadon should be taken 15-30 minutes before meals. The usual oral dose of Dopadon is as follows :
Adults: 1-2 Dopadon tablet (10 to 20 mg) or 10-20 ml Dopadon suspension every 4-8 hours daily.
Children: 0.2-0.4 mg/kg Dopadon suspension or 0.4-0.8 ml/Kg Dopadon suspension every 4-8 hours
daily. For acute nausea and vomiting, maximum period of treatment is 12 weeks. Dose for the lactating
mothers: The usual dosage of Dopadon for insufficient milk supply is 20 mg.
Side Effects:
Hyperprolactinemia (1.3%) may produce during the treatment with domperidone, which may result in
galactorrhea, breast enlargement, soreness and reduced libido. Dry mouth (1%), thirst, headache (1.2%),
nervousness, drowsiness (0.4%), diarrhoea, skin rash and itching may occrr, Extrapyramidal reactions are
seen in 0.05% of patients in clinical studies.
Dopadon 10mg 10pcs
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