Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase, the ‘Proton Pump’ of the gastric parietal cell.
Dosage and administration
Esomeprazole capsules should be swallowed whole and taken one hour before meal.
Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks. The majority of patients are healed within 4 to 8 weeks. For patients who don’t heal after 4-8 weeks, an additional 4-8 weeks of treatment may be considered.
Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily (Clinical studies did not extend 6 months).
Symptomatic GERD: 20 mg Once Daily for 4 Weeks. If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered.
Helicobacter Pylori eradication: Triple Therapy to reduce the risk of Duodenal Ulcer recurrence-Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days, Clarithromycin 500 mg Twice Daily for 10 days.
Zollinger-Ellison Syndrome: The dose is 40 mg twice daily. The dosage should be adjusted individually and treatment continued as long as clinically indicated. Acid related Dyspepsia: 20-4o mg once daily for 2-4 weeks according to response. Duodenal ulcer: 20 mg once daily for 2-4 weeks.
Gastric ulcer: 20-40 mg once daily for 4-8 weeks.
Side Effects:
The most frequently occurring adverse events reported with Esomeprazole include headache, diarrhoea, nausea, flatulence, abdominal pain, constipation and dry mouth. There are no difference in types of related adverse events seen during maintenance treatment upto 12 months compared to short term treatment.
Storage
Protect from light, Store in dry place.Keep out of reach of children
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