INDICATION
Gabastar® (Gabapentin) is indicated for
Neuropathic Pain
Adjunctive therapy in partial seizure and secondary generalized seizure
DOSAGE & ADMINISTRATION
Neuropathic Pain: The treatment may be initiated as a single 300 mg dose on
Day-1, than 300 mg twice on Day-2 and 300 mg thrice on Day-3. The dose can
be subsequently be titrated up as needed for pain relief to a daily dose of 1800
mg (divided TID).
Epilepsy: Patients over 12 years of age – the effective dose of Gabastar® is 900
to 1800 mg/day given in three divided doses. The starting dose is 300 mg three
times a day.
Paediatric patients age 3-12 years- the starting dose should range from 10-15
mg/kg/day in 3 divided doses, and the effective dose reached by upward
titration over a period of approximately three days.
In case of renal impaired patients Gabapentin doses must be reduced.
Gabapentin can be taken orally with or without food.
CONTRAINDICATION
Gabapentin is contraindicated in patients who have known hypersensitivity to
the drug.
PRECAUTION
Patients should not drive a car or operate complex machinery until they have
gained sufficient experiences about Gabapentin whether or not it affects their
mental and/ or motor performance adversely.
SIDE EFFECTS
Fatigue, Dizziness, ataxia, weight gain, peripheral edema, dry mouth and
somnolence may occur.
DRUG INTERACTIONS
Antacids may reduce the bioavailability of Gabapentin by up to 20 %.
Cimetidine may alter its reanal excretion. Gabapentin does not interact with
other anti-epileptic drug or with oral contraceptive preparations.
USE IN PREGNANCY AND LACTATION
Pregnancy category C. it should be used during pregnancy only if potential
benefits justifies the potential risk to the fetus.
Gabapentin may be secreted through the breast milk. So it should be used
during lactation only if potential benefits justifies the potential risk to the baby.
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