Composition
Insimet 500 : Each film coated tablet contains Metformin Hydrochloride BP 500 mg.
Insimet 850 : Each film coated tablet contains Metformin Hydrochloride BP 850 mg.
Insimet XR 500: Each extended release tablet contains Metformin Hydrochloride BP 500 mg.
Description
Insimet (Metformin) is a biguanide type oral antihyperglycemic drug used in the management of
type 2 diabetes. It lowers both basal and postprandial plasma glucose. Its mechanism of action is
different from those of sulfonylureas and it does not produce hypoglycemia. Insimet decreases
hepatic glucose production, decreases intestinal absorption of glucose and improves insulin
sensitivity by an increase in peripheral glucose uptake and utilization.
Indication
Insimet, as monotherapy, is indicated as an adjunct to diet and exercise to improve glycemic
control in patients with type 2 diabetes. Insimet is also indicated for use in combination therapy
with an oral hypoglycemic agent or insulin when diet and exercise plus the single agent do not
result in adequate glycemic control.
Dosage and Administration
Dosage of Insimet or Insimet XR must be individualized on the basis of both effectiveness and
tolerance, while not exceeding the maximum recommended daily dose. The maximum
recommended daily dose of Insimet is 2550 mg in adults and 2000 mg in pediatric patients (10-
16 years of age); the maximum recommended daily dose of Insimet XR in adults is 2000 mg.
Insimet should be given in divided doses with meals while Insimet XR should generally be given
once daily with the evening meal. Insimet XR tablet must be swallowed whole and never be
crushed or chewed. Insimet or Insimet XR should be started at a low dose, with gradual dose
escalation, both to reduce gastrointestinal side effects and to permit identification of the
minimum dose required for adequate glycemic control of the patient.
Recommended Dosing Schedule
a) Adults: The usual starting dose of Insimet is 500 mg twice a day or 850 mg once a day, given
with meals. Dosage increases should be made in increments of 500 mg weekly or 850 mg every
2 weeks, up to a total of 2000 mg per day, given in divided doses. Patients can also be titrated
from 500 mg twice a day to 850 mg twice a day after 2 weeks. Doses above 2000 mg may be
better tolerated given three times a day with meals. The usual starting dose of Insimet XR is 500
mg once daily with the evening meal. Dosage increases should be made in increments of 500 mg
weekly, up to a maximum of 2000 mg once daily with the evening meal. If glycemic control is not
achieved on Insimet XR 2000 mg once daily, a trial of Insimet XR 1000 mg twice daily should be
considered. Patients receiving Insimet treatment may be safely switched to Insimet XR once
daily at the same total daily dose, up to 2000 mg once daily.
b) Pediatrics: The usual starting dose of Insimet is 500 mg twice a day, given with meals. Dosage
increases should be made in increments of 500 mg weekly up to a maximum of 2000 mg per
day, given in divided doses. Safety and effectiveness of Insimet in pediatric patients below 10
years have not been established.
Use in Pregnancy & Nursing mother
Pregnancy: Pregnancy Category B. Most experts recommend that insulin should be used during
pregnancy to maintain blood glucose levels as close to normal as possible. Both Metformin
immediate and extended release tablets should not be used during pregnancy unless clearly
needed.
Nursing Mother:Â Because the potential for hypoglycemia in nursing infants may exist, a decision
should be made whether to discontinue nursing or to discontinue the drug, taking into account
the importance of the drug to the mother.
Paediatric & Geriatric use:Â Safety and effectiveness in paediatric patients have not been
established. Dosage adjustment should be based on a careful assessment of renal function in
elderly patients.
Insimet 500mg 5pcs
৳ 20
Description
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