Brand Name: Intobac Eye Drop (0.3%) 5ml
Manufacturer: Incepta Pharmaceuticals Limited
Indications
For the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany its use.
Therapeutic Class
Ophthalmic antibacterial drugs
Pharmacology
Tobramycin interferes with bacterial protein synthesis by binding to 30S and 50S ribosomal subunits, resulting in a defective bacterial cell membrane.
Dosage & Administration
Eye Drops: In mild to moderate disease, 1 drop into the affected eye(s) every 4 hours. In severe infections, 1 drop into the affected eye(s) hourly until improvement, following which dosage should be reduced prior to discontinuation.Eye Ointment: In mild to moderate disease it should be applied thinly and evenly into the conjunctival sac of the affected eyes 2 to 3 times per day. For severe cases it should be applied thinly and evenly into the conjunctival sac of the affected eyes 3 to 4 times per day. Following improvement, treatment should be reduced prior to discontinuation.
Interaction
Specific drug interaction studies on Tobramycin ophthalmic preparation have not been established
Contraindications
In patients with known hypersensitivity to any component of the product. Partial crossallergenicity to other aminoglycosides has been established.
Side Effects
The most frequent adverse reactions to Tobramycin are localized ocular toxicity and hypersensitivity, including lid itching and swelling and conjunctival erythema. These reactions occur in less than 3% of patients treated.
Pregnancy & Lactation
Pregnancy: This drug should be used during pregnancy only if clearly needed.Lactation: Because of the potential for adverse reactions in nursing infants from Tobramycin, a decision should be made whether to discontinue nursing the infant or discontinue the drug, taking into account the importance of the drug to the mother.
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