LocolTMÂ 10 tablet: Each film coated tablet contains Atorvastatin Calcium INN equivalent to 10 mg Atorvastatin. LocolTMÂ 20 tablet: Each film coated tablet contains Atorvastatin Calcium INN equivalent to 20 mg Atorvastatin.
Dosage and administration:
The patient should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on the diet during treatment with Atorvastatin. Hypercholesterolemia (Heterozygous familial and non-familial) and mixed dyslipidemia (Fredrickson Types IIa and IIb): The recommended starting dose of Atorvastatin is 10 or 20 mg once daily. The dosage range is 10 to 80 mg once daily. Atorvastatin can be administered as a single dose at any time of the day, with or without food. Therapy should be individualized according to goal of therapy and response. Heterozygous familial hypercholesterolemia in pediatric patients (10-17 years of age): The recommended starting dose of Atorvastatin is 10 mg/day; the maximum recommended dose is 20 mg/day. Adjustments should be made at intervals of 4 weeks or more. Homozygous familial hypercholesterolemia (FM): The dosage of Atorvastatin in patients with Homozygous FH is 10 to 80 mg daily. Atorvastatin can be used as an adjunct to other lipid-lowering treatments (e.g. LDL apheresis) in these patients or if such treatments are unavailable. Concomitant therapy: Atorvastatin may be used in combination with a bile acid binding resin for additive effect. The combination of HMG-CoA reductase inhibitors and fibrates should generally be avoided. Dosage in patients with renal Insufficiency: Renal disease does not affect the plasma concentrations nor LDL-C reduction of Atorvastatin; thus, dosage adjustment in patients with renal dysfunction is not necessary.
Side effect:
Atorvastatin is generally well tolerated. Adverse reactions have usually been mild and transient. The most frequent adverse events thought to be related to Atorvastatin were constipation, flatulence, dyspepsia, and abdominal pain.
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