Description
Pregabalin is a structural derivative of gamma-amino-butyric acid (GABA). It does not bind directly to GABAA, GABAB, orbenzodiazepine receptors. It binds with high affinity to the alpha 2-delta site (an auxilliary subunit of voltage-gated calcium channels) in central nervous system tissues. Oral bioavailability of Pregabalin is 90%. Pregabalin is eliminated largely by renal excretion, and has an elimination half-life of about 6 hours. Pregabalin can be taken with or without food. Indications and Uses
Neuralgia: (a) pain from diabetic neuropathy, (b) post herpetic neuralgia. Partial seizure / epilepsy: Pregabalin is also indicated as adjunctive therapy for adult patients with partial onset seizures.
Contraindications
Pregabalin is contraindicated in patients with known hypersensitivity to Pregabalin.Dosage and Administration
Diabetic neuropathic pain:
The maximum recommended dose of Pregabalin is 100 mg three times a day in patients with creatinine clearance of at least
60 mL/min. Dosing should begin at 50 mg three times a day and may be increased to 300 mg/day within 1 week based on efficacy
and tolerability.
Postherptic neuralgia:
The recommended dose of Pregabalin is 75 to 150 mg two times a day, or 50 to 100 mg three times a day in patients with creatinine
clearance of at least 60 mL/min. Dosing should begin at 75 mg two times a day, or 50 mg three times a day and may be increased
to 300 mg/day within 1 week based on efficacy and tolerability.
Side Effects
Pregabalin is well tolerated but a few side effects like dizziness, somnolence and blurred vision may occur.
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