Indications
- Major depressive episodes
- Generalized anxiety disorder
- Obsessive-compulsive disorder
- Panic disorder with or without agoraphobia &
- Social anxiety disorder (social phobia).
Therapeutic Class
Pharmacology
Dosage
- Initial: 10 mg once daily
- Maximum: 20 mg once daily.
Panic disorder:
- Initial: 5 mg once daily
- Maximum: 20 mg once daily.
Social anxiety disorder (social phobia):
- Initial: 10 mg once daily (maybe decreased up to 5 mg)
- Maximum: 20 mg once daily.
For elderly (>65 years of age) & hepatic impairment patients:
- Initial: 5 mg once daily
- Maximum: 10 mg once daily.
Renal impairment: Caution is advised in severe renal impaired patients.
If the dose is increased to 20 mg, this should occur after a minimum of one week.
Paediatric use: Safety and effectiveness in children below the age of 12 years have not been established.
Administration
Interaction
Contraindications
Side Effects
Pregnancy & Lactation
Precautions & Warnings
Overdose Effects
Management: There is no specific antidote. Establish and maintain an airway, ensure adequate oxygenation and respiratory function. Gastric lavage and the use of activated charcoal should be considered. Gastric lavage should be carried out as soon as possible after oral ingestion. Cardiac and vital signs monitoring are recommended along with general symptomatic supportive measures. ECG monitoring is advised in case of overdose, in patients with congestive heart failure/bradyarrhythmias, in patients using concomitant medications that prolong the QT-interval, or in patients with altered metabolism, e.g. liver impairment.
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