Active Ingredient:
Each sustained release tablet contains 2.6 mg Nitroglycerin USP. Each sustained release capsule contains 2.6 mg Nitroglycerin
USP as sustained release pellets. Properties & Effects: Nitrin® SR is a potent coronary vasodilator. It also reduces venous return and thus left ventricular work. Nitrin® SR possesses sustained effects because its absorption from the gastrointestinal tract is long lasting and continuous due to the sustained release of active substance from the formulation.
Indications:
Prevention and treatment of effort and vasospastic angina. Supplementary treatment of heart failure refractory to digitalis and diuretic
treament.
Dosage and Administration:
Adults and elderly patients:
Dosage should be tailored to the requirements of the individual patient depending on the severity of illness and the occurrence of side-effects but will usually be 1 or 2 tablets/capsules taken 2-3 times daily before meals.
Children: Not recommended. Nitrin® SR is for oral administration. Tablet/capsule must be swallowed whole and not chewed.
Contraindications:
Nitroglycerin USP should not be used in patients with marked anaemia, head trauma, cerebral haemorrhage or incipient glaucoma. Sildenafil has been shown to potentiate the hypotensive effects of nitrates, and its co-administration with nitrates or nitric oxide donors is therefore contraindicated. Special Warnings and Precautions: As with other drugs for the treatment of angina pectoris, abrupt discontinuation of therapy may lead to exacerbation of symptoms. When discontinuing long term treatment, the dosage should be reduced gradually over several days.
Side Effects:
Headache, dizziness, mild gastrointestinal symptoms may occur. They disappear on dosage reduction and usually do not necessitate the
discontinuation of the treatment.
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