Indications
Nuprafen is indicated in mild to moderate pain such as dysmenorrhoea,
migraine and for the treatment of rheumatoid arthritis, osteoarthritis
(degenerative arthritis), ankylosing spondylitis, juvenile rheumatoid
arthritis, acute gout, and acute musculoskeletal disorders.
Dosage and Administration
Adults : For rheumatoid arthritis, osteoarthritis and ankylosing
spondylitis, the usual dose is 500 mg to 1 g per day taken in two divided
doses at 12 hour intervals. For mild to moderate pain such as primary
dysmenorrhoea, acute tendinitis and bursitis, the usual initial dose is 500
mg followed by 250 mg every 6 or 8 hours. The total daily dose should
not exceed 1250 mg.
In acute gout an initial dose of 750 mg followed by 250 mg every 8 hours
has been suggested until the attack subsides.
For juvenile arthritis : A dose of 10 mg/kg body weight daily in 2 divided
doses in children over 5 years of age has been recommended.
In the acute phase of the following cases a loading dose of 750 mg per
day is recommended.
¨ In patients reporting severe night time pain and morning stiffness.
¨ In patients being switched to Nuprafen (Naproxen) from a high dose
of another anti-rheumatic compound.
¨ In osteo-arthrosis where pain is the predominant symptom.
Side Effects
Occasional skin rashes and angio-oedema have been reported. The
following additional occurrences have been reported with Naproxen :
nausea, vomiting, abdominal discomfort, epigastric distress, headache,
inability to concentrate, insomnia, tinnitus and vertigo.
Thrombocytopenia, jaundice, aplastic anaemia, haemolytic anaemia,
peptic ulceration, fatal hepatitis, hearing impairment, cognitive
dysfunction, anaphylactic reactions to Naproxen and Naproxen sodium
formulations and nephropathy may occur rarely.
Mild peripheral oedema has been observed in a few patients receiving
Naproxen. Although sodium retention has not been reported in
metabolic studies, it is possible that patients with questionable or
compromised cardiac function may be at a greater risk when taking
Naproxen.
Use in Special Populations
Pregnancy :Â There are no adequate and well controlled studies in pregnant
women. Because animal reproduction studies are not always predictive of
human response, Naproxen should be used during pregnancy only if the
potential benefits justify the potential risks to the foetus.
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