Presentation
Prebalin 50: Each capsule contains Pregabalin INN 50 mg.
Prebalin 75: Each capsule contains Pregabalin INN 75 mg.
Prebalin 150: Each capsule contains Pregabalin INN 150 mg.
Pharmacodynamic Properties
The active substance, pregabalin is a gamma-aminobutyric acid analogue. Pregabalin binds to
an auxiliary subunit (α2-δ protein) of voltage-gated calcium channel in the central nervous
system, potently displacing [3H]-gabapentin.
Pharmacokinetic Properties
Pregabalin is rapidly absorbed when administered in the fasted state. Oral bioavailability is
90% and is independent of dose. Pregabalin is eliminated from the systemic circulation
primarily by renal excretion as unchanged drug. Mean elimination half-life of Pregabalin is 6.3
hours.
Indications
Prebalin is indicated for the following condition- v Fibromyalgia
v Neuropathic pain associated with diabetic peripheral neuropathy
v Postherpetic neuralgia
v Generalized Anxiety Disorder (GAD) in adults
v As adjunctive therapy in adults with partial seizures with or without secondary
generalization
Dosage & Administration
Prebalin is given orally with or without food. The dose range of Prebalin is 150 to 600 mg
per day given in either two or three divided doses. When discontinuing Prebalin, taper
gradually over a minimum of 1 week.
Fibromyalgia: Adult over 18 years; The recommended dose for fibromyalgia is 300 to 450
mg/day. Dosing should begin at 75 mg two times a day (150 mg/day) and may be increased
up to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability.
Neuropathic pain: Adult over 18 years; Initially 150 mg daily in 2-3 divided doses, increased
if necessary after 3-7 days to 300 mg daily in 2-3 divided doses, increased further if necessary
after 7 days to maximum 600 mg daily in 2-3 divided doses.
Postherpetic neuralgia: Adult over 18 years; The recommended dose for postherpetic
neuralgia is 75 to 150 mg two times daily or 50 to 100 mg three times a day (150 to 300
mg/day). Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg
/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability.
Generalized Anxiety Disorder: Adult over 18 years; Initially 150 mg daily in 2-3 divided
doses, increased if necessary at 7-day intervals in steps of 150 mg daily; maximum 600 mg
daily in 2-3 divided doses.
Epilepsy: Adult over 18 years; Initially 25 mg twice daily, increased at 7-day intervals in steps
of 50 mg daily to 300 mg daily in 2-3 divided doses, increased further if necessary after 7 days
to maximum 600 mg daily in 2-3 divided doses
prebalin-75mg 1pcs
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