Brand Name: Prosan 50
Manufacturer:Â Beximco Pharmaceuticals Ltd.
Indications
It is indicated for the treatment of hypertension. It may be used alone or
in combination with other antihypertensive agents.
Dosage and Administration
The usual starting dose is 50 mg once daily, with 25 mg used in patients
with possible depletion of intravascular volume (e.g., patients treated with
diuretics) and patients with a history of hepatic impairment. It can be
administered once or twice daily with total daily doses ranging from 25
mg to 100 mg.
Contraindications
Losartan Potassium is contraindicated in patients who are hypersensitive
to the active ingredient or any component of the drug.
Drug Interactions
No drug interactions of clinical significance have been identified.
Compounds that have been studied in clinical pharmacokinetic trials
include Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine,
Ketoconazole and Phenobarbital.
Side Effects
In clinical trials, dizziness was the only side effect reported that occurred
with an incidence greater than placebo in 1% patients treated with
Losartan. Rarely, rash was reported, although the incidence in controlled
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THERAPEUTIC INDEX
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clinical trial was less than placebo. Angio-oedema, involving swelling of
the face, lips and/or tongue, has been reported rarely in patients treated
with Losartan. The incidence of cough is similar to placebo and
significantly lower than that observed with ACE inhibitors.
Use in Special Populations
Pregnancy : Prosan must be discontinued as soon as possible when
pregnancy is detected.
Lactation : It should not be prescribed during lactation, as there is no
information in human on the passage of Losartan into breast milk.
Children : There are no data on the safety or efficacy of Losartan in
children.
Elderly : In elderly patients up to 75 years of age, no dosage adjustment is
necessary
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