Brand Name: Purifen 300
Manufacturer: Incepta Pharmaceuticals Limited
Indications
• Relief of sign and symptoms of osteoarthritis
• Rheumatoidal disorders such as osseous rheumatism, ankylosing spondilitis, juvenile arthritis, muscular rheumatism, degenerative joint diseases
• Acute symptomatic treatment of painful menstruation (primary dysmenorrhoea)
• Common headache and fever
• Symptomatic treatment of mild to moderate pain, such as muscle pain, headache and dental pain
• As adjuvant with common cold and influenza associated with headache
Dosage & Administration
The dosage must be adjusted to the seriousness of the syndrome and the complaints of the patient. During chronic pain, the dosage must be adapted to the lowest effective dose.
The recommended dosage is 600-900 mg Dexibuprofen per day, at 2-3 divided doses. The dosage can be raised temporarily up to 1200 mg Dexibuprofen per day in patients with acute disorders or exacerbations. The maximum daily dose is 1200 mg.
At dysmenorrhea, a dosage of 600 up to 900 mg Dexibuprofen per day, at divided dose.
At elderly people, lowest effective dose is recommended. The dosage can be raised to adult dosage if well tolerated.
Hepatic impairment: Patients with mild to moderate liver function impairments must start with low amounts, and must closely be monitored. Dexibuprofen should not be used in patients with serious liver function impairments.
Renal impairment: The start amount must be reduced at patients with mild to moderate kidney function impairments. Dexibuprofen cannot be used patients with serious kidney function impairments.
Children Dose
10-15 mg/kg daily in 2-4 divided doses
Side Effects
Clinical experience has shown that adverse effects of Dexibuprofen are similar to those of racemic ibuprofen. Common side-effects are dyspepsia, diarrhea, fatigue, and headache, nausea, vomiting, abdominal pain.
Use in Pregnancy & Lactation
Pregnancy: Although no teratogennic impact has been observed in the animal-experimental research with dexibuprofen or ibuprofen, the use should be avoided during the pregnancy. However, animal reproduction studies are not always predictive of human response. Because of the known effects of nonsteroidal anti-inflammatory drugs on the fetal cardiovascular system (closure of ductus arteriosus), use during late pregnancy should be avoided.
Lactation: Studies at people have shown that racemic ibuprofen proceed in small to negligible degree in mother milk. So, Dexibuprofen should be used with cautions in nursing mothers
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