Brand Name: RivaXa 2.5
Manufacturer:Â Square Pharmaceuticals Ltd.
Indication:Â
Rivaroxaban 2.5 mg: For the prevention of atherothrombotic events in adult patients after an Acute Coronary Syndrome (ACS) with elevated cardiac biomarkers (Troponin or CK-MB).
Rivaroxaban 10-20 mg: To reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, Deep vein thrombosis (DVT) & pulmonary embolism (PE) and reduction in the risk of recurrence of DVT and of PE , For the prophylaxis of DVT, which may lead to PE in patients undergoing knee or hip replacement surgery.
Dosage & Administration:
Rivaroxaban 2.5 mg: The recommended dose is 2.5 mg twice daily. Patients should also take a daily dose of 75-100 mg Aspirin or a daily dose of 75-100 mg Aspirin in addition to either a daily dose of 75 mg Clopidogrel Rivaroxaban 10-20 mg: • Nonvalvular Atrial Fibrillation: For patients with Creatinine Clearance >50 ml/min: 20 mg orally, once daily with the evening meal. For patients with Creatinine Clearance 15-50 ml/min: 15 mg orally, once daily with the evening meal. Rivaroxaban provides protection from day one and should be continued for long term
INDICATION AND USE
1. Mild to severe hypertension, where it may be used alone or in
combination with thiazide diuretics
2. Congestive heart failure
3. To reduce the risk of stroke, myocardial infarction and death from
cardiovascular events in patients with a history of cardiovascular
diseases
4. Proteinuric non-diabetic nephropathy
CONTRAINDICATION
Ramipril is contraindicated in patients who are hypersensitive to any
component of this product and in patients with a history of angioedema
related to previous treatment with a ACE inhibitor.
SIDE EFFECT
Ramipril is generally well tolerated. Dizziness, headache, fatigue and
asthenia are commonly reported side effects. Other side effects occurring
less frequently include symptomatic hypotension, cough, nausea, vomiting,
diarrhoea, rash, urticaria, oliguria, anxiety, amnesia, etc. Angioneurotic
edema, anaphylactic reactions and hyperkalemia have also been reported
rarely.
Warnings : Ramipril should be used with caution in patients with impaired
PREPARATIONS
renal function, hyperkalemia, hypotension, surgery/anesthesia and impaired
hepatic function.
USE IN PREGNANCY
Pregnancy should be excluded before start of treatment with ramipril and
avoided during treatment. However, if pregnancy is detected, ramipril should
be discontinued as early as possible unless continued use is considered life
saving.
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