Brand Name: Rutix 200
Manufacturer: Square Pharmaceuticals Ltd.
INDICATION
Rutix® tablets are indicated for the treatment of adults with mild to moderate
infections caused by susceptible strains.
Lower Respiratory Tract: Acute bacterial exacerbation of chronic bronchitis
lung abscess, pneumonia. Gastrointestinal Tract: Enteric fever, shigellosis.
Multi-drug-resistant Tuberculosis. Skin and skin structures: Uncomplicated
skin and skin structure infections. Sexually Transmitted Diseases: Acute,
Uncomplicated urethral and cervical gonorrhoea. Nongonococcal urethritis
and cervicitis. Mixed infections of the urethra and cervix. Urinary tract:
Uncomplicated Urinary Tract Infections, Complicated urinary tract infections.
DOSAGE AND ADMINISTRATION
General dosage recommendations: The dose of ofloxacin is determined by
the type and severity of the infection. The dosage range for adults is 200 mg
to 800 mg daily. Up to 400 mg may be given as a single dose, preferably in
the morning, larger doses should be given as two divided doses. Rutix®
tablets should be swallowed with liquid; they should not be taken within two
hours of intake of magnesium/aluminium containing antacids or iron
preparations since reduction of absorption of ofloxacin can occur.
Enteric fever: For adults 200 mg, every 12 hours, for 5 days. For children 15
mg/kg/day in 2 divided doses for 3 days.
CONTRAINDICATION AND PRECAUTION
Ofloxacin should not be used in-patients with known hypersensitivity to 4-
fluoroquinolone antibacterials. It is contraindicated in-patients with a history
of epilepsy or with a lowered seizure threshold. Ofloxacin is usually
contraindicated in children or growing adolescents and in pregnant or
breast feeding women.
Patients being treated with Ofloxacin should not expose themselves
unnecessarily to strong sunlight and should avoid UV rays. Caution is
recommended if the drug is to be used in psychotic patients or in-patients
with a history of psychiatric disease.
SIDE EFFECT
Ofloxacin is generally well tolerated and clinical side-effects of ofloxacin has
been quite low. Among the adverse effects gastrointestinal and central
nervous systems’ reactions are common. Nausea, rash, vomiting, abdominal
pain, diarrhoea and gastrointestinal distress are the gastrointestinal adverse
effects. Common central nervous system reactions are headache, dizziness
and insomnia.
DRUG INTERACTION
Antacids containing magnesium, aluminium or calcium may decrease
absorption of ofloxacin. Iron or Zinc may decrease oral absorption of
ofloxacin.
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