Indications
Primary hypercholesterolaemia (type IIa including heterozygous familial hypercholesterolaemia), mixed dyslipidaemia (type IIb) or homozygous familial hypercholesterolaemia in patients who have not responded adequately to diet and other appropriate measures; prevention of cardiovascular events in patients at high risk of a first cardiovascular event.
Therapeutic Class
Pharmacology
Dosage & Administration
Hypercholesterolaemia, initially 5-10 mg once daily increased if necessary at intervals of at least 4 weeks to 20 mg once daily, increased after further 4 weeks to 40 mg daily only in severe hypercholesterolaemia; elderly initially 5 mg once daily; patient of asian origin, initially 5 mg once daily increased if necessary to max. 20 mg daily. Initially 5 mg once daily with concomitant fibrate increased if necessary to max. 20 mg daily. Prevention of cardiovascular events, 20 mg once daily.
Side Effects
Rosuvastatin is generally well tolerated. The common side effects are headache, myalgia, asthenia, constipation, dizziness and abdominal pain. It may rarely cause myositis, rhabdomyolysis, pancreatitis and hypersensitivity reaction.
Pregnancy & Lactation
Pregnancy Category X. Teratogenic effects. Rosuvastatin is contraindicated in pregnancy and lactation. Women of child bearing potential should use appropriate contraceptive measures. If a patient becomes pregnant during use of this product, treatment should be discontinued immediately.
Rosuvastatin is excreted in the milk of rats. There are no data with respect to excretion in milk in humans
Reviews
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