Indication:
Non-insulin dependent (type-II) diabetes, whenever blood sugar levels cannot be
controlled adequately by diet, physical exercise and weight reduction.
Secrin (Glimepiride) is also indicated for use in combinaton with insulin to lower blood
glucose in patients whose hyperglycaemia can not be controlled by diet and exercise or
in conjunction with an oral hyperglycaemic agent.
Dosage and Administration:
In principal, the dosage of Glimepiride is governed by the desired blood sugar level. The
dosage of Glimepiride must be the lowest which is sufficient to achieve the desired
metabolic control.
The initial and the maintenance dosage are set based on the results of regular check of
glucose in blood and urine. Monitoring of glucose levels in blood and urine also serves
to detect either primary or secondary failure of therapy.
Administration :
Glimepiride tablets must be swallowed without chewing and with sufficient amounts of
liquid (approximately one or two glass).
Contraindication:
Glimepiride is not suitable for the treatment of insulin dependent (type-I) diabetes
mallitus, or of diabetic precoma or coma. Glimepiride must not be used in patients
hypersensitive Glimepiride, other sulphonylureas, other sulphonamides. In patients with
severe impairment of renal or hepatic function, a changeover to insulin is indicated.
Precaution:
In the initial weeks of treatment, the risk of hypoglycaemia may be increased and
necessitates especially careful monitoring. If such risk is present it may be necessary to
adjust the dosage of Glimepiride. Hypoglycaemia can almost always be promptly
controlled by immediate intake of carbohydrates (glucose or sugar, e.g., in the form of
sugar lumps, sugar-sweetened fruit juice or sugar-sweetened tea.
Side effect:
Hypoglycaemia, temporary visual impairment, nausea, vomiting, diarrhoea, abdominal
pain, urticaria, fall in blood pressure.
Drug interaction:
Potentiation of the blood-sugar-lowering effect may occur with insulin and other oral
anti-diabetic, ACE inhibitors, allopurinol, anabolic steroids and male sex hormones,
chlormphenicol, coumarin derivatives, fluoxetine, MAO inhibitors, miconazole, paraaminosalicylic
acid, pentoxifylline (high dose parenteral) , phenylbutazone,
oxyphenbutazone, quinolones, salicylates, sulfonamides, tetracyclines, beta blockers.
Weakening of the blood sugrar-lowering effect may occur with acetazolamide,
barbiturates, corticosteriods, diazoxide, diuretics, epinephrine and other
sympathomimetic agents, laxatives, oestrogens and progestogens,
phenothiazines,phenytoin, rifampicin, thyroid hormones, H2- receptor antagonists,
clonidine and reserpine may lead to either Potentiation or weakening of the bloodsugar-lowering
effect.
Both acute and chronic alcohol intake may potentiate or weaken the blood-sugarlowering
action of glimepiride unpredictably.
Secrin 1 10pcs
৳ 60
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