Indications
Therapeutic Class
Pharmacology
Dosage & Administration
Abdominal infections, Respiratory tract infections, Skin and skin structure infections, Urinary tract infections:
- Adult:Â Mild to moderate infections: 1-2 g daily in 2 divided doses. Severe infections: Up to 4 g daily in 2 divided doses. Doses are given by deep IM inj or IV infusion over at least 30 min.
- Child:Â Neonates: 30 mg/kg 12 hrly, may increase to 50 mg/kg for Pseudomonas infections; >30 days Mild to moderate infections: 100 mg/kg daily in 2 divided doses. Severe infections: Up to 150 mg/kg daily in 2 or 3 divided doses. Total dose should not exceed the recommended adult dosage.
Empiric therapy for febrile neutropenic patients:
- Adult:Â Up to 6 g daily in 3 divided doses. Doses are given by deep IM inj or IV infusion over at least 30 min.
Interaction
Contraindications
Side Effects
Pregnancy & Lactation
Precautions
Overdose Effects
Symptoms: Encephalopathy (disturbance of consciousness including confusion, hallucinations, stupor, and coma), myoclonus, seizures, neuromuscular excitability and non-convulsive status epilepticus.
Management: Supportive treatment. Haemodialysis is recommended in case of renal insufficiency.
Reconstitutions
IV infusion:Â Add 5 mL, 10 mL, or 10 mL of a compatible IV soln to a vial labeled as containing 500 mg, 1 g, or 2 g, respectively, to provide soln containing approx 100 mg/mL, 100 mg/mL, or 160 mg/mL of the drug, respectively. The appropriate dose of the drug should then be added to a compatible IV soln.
IM inj:Â Add 1.3 mL or 2.4 mL of an appropriate diluent (e.g. sterile water for inj, NaCl 0.9%) to a vial labeled as containing 500 mg or 1 g respectively, to provide a soln containing approx 280 mg/mL.
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