Tyclav®
Amoxicillin and Clavulanic Acid
Tablet, Powder for Suspension and Injections
Description
Tyclav® is an antibacterial combination consisting of the antibiotic Amoxicillin
and the b-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad
spectrum of bactericidal activity against many Gram-positive & Gram-negative
microorganisms but it is susceptible to degradation by b-lactamases and
therefore the spectrum of activity does not include microorganisms, which
produce these enzymes. Clavulanic acid possesses the ability to inactivate a
wide range of b-lactamase enzymes commonly found in microorganisms
resistant to penicillins and cephalosporins. Thus Clavulanic acid in
combination of Amoxicillin and Clavulanic acid protects Amoxicillin from
degradation by b-lactamase enzymes and effectively extends the antibiotic
spectrum to embrace a wide range of microorganisms.
Indication and Usage
Tyclav® is indicated for short-term treatment of bacterial infections at the
following sites:
1. Upper respiratory tract infections (including ENT); e.g., tonsillitis, sinusitis,
otitis media.
2. Lower respiratory tract infections; e.g., acute and chronic bronchitis, lobar
and bronchopneumonia.
3. Genito-urinary tract infections; e.g., cystitis, urethritis, pyelonephritis.
4. Skin and soft tissue infections.
5. Bone and joint infections; e.g., osteomyelitis.
6. Other infections; e.g., septic abortion, puerperal sepsis, intra-abdominal
sepsis, etc.
Dosage and Administrations
Dose of Tablets
Adults and children over 12 years:
The usual adult dose is one Tyclav® 625 Tablet every 12 hours or one Tyclav®
375 Tablet every 8 hours. For more severe infections and infections of the
respiratory tract, the dose should be one Tyclav® 1 g Tablet every 12 hours or
one Tyclav® 625 Tablet every 8 hours.
Dose of Powder for Suspensions
Tyclav® Powder for Suspension:
Neonate: 0.25 ml/kg 3 times daily.
1 month–1 year: 0.25 ml/kg 3 times daily, dose doubled in severe infection.
1–6 years: 5 ml 3 times daily or 0.25 ml/kg 3 times daily, dose doubled in
severe infection.
6–12 years: 10 ml 3 times daily, dose doubled in severe infection.
Tyclav® bid Powder for Suspension:
2 month-2 years: 0.15 ml/kg twice daily, doubled in severe infection.
2-6 years (13-21 kg): 2.5 ml twice daily, doubled in severe infection.
7-12 years (22-40 kg): 5 ml twice daily, doubled in severe infection.
12-18 years (over 40 kg): 10 ml twice daily, three times daily in severe
infection.
Dose of Injections:
Adults
Usually 1.2 g every 8 hours, increased in more severe infections to 1.2 g
every 6 hours.
Adult dosage for surgical prophylaxis
The usual dose is 1.2 g at induction, for high risk procedures (e.g., colorectal
surgery) up to 2-3 further doses of 1.2 g may be given every 8 hours.
Children
0 to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period
and in premature infants).
3 months to 12 years: Usually 30 mg/kg every 8 hours increased in more
serious infections to 30 mg/kg every 6 hours.
Tyclav 1.2 IV
৳ 300
Description
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