Brand Name: Virux 500
Manufacturer : Square Pharmaceuticals Ltd.
INDICATION
Virux® IV Injection is indicated in:
1. Acute clinical manifestations of Herpes simplex virus in immunocompromised patients
2. Severe primary or non-primary genital herpes in immune competent patients
3. Varicella zoster virus infection in immunocompromised patients
4. Herpes zoster (shingles) in immune competent patients who show very severe acute
local or systemic manifestations of the disease
5. Herpes simplex encephalitis
CONTRAINDICATION
Acyclovir IV Injection is contraindicated in patients known to be hypersensitive to Acyclovir
or Valacyclovir.
PRECAUTION
Acyclovir IV injection is intended for intravenous infusion only and should not be used
through any other route. Reconstituted Acyclovir IV Infusion has a pH of approximately 11.0
and should not be administered by mouth.
Acyclovir IV injection as infusion must be given over a period of at least one hour in order to
avoid renal tubular damage. It should not be administered as a bolus injection. Acyclovir IV
infusion must be accompanied by adequate hydration. Since maximum urine concentration
occurs within the rst few hours following infusion, particular attention should be given to
establish sucient urine ow during that period. Concomitant use of other nephrotoxic
drugs, pre-existing renal disease and dehydration increase the risk of further renal
impairment by Acyclovir.
As Acyclovir has been associated with reversible encephalopathic changes, it should be
used with caution in patients with neurological abnormalities, signicant hypoxia or serious
renal, hepatic or electrolyte abnormalities.
PREGNANCY AND LACTATION
Pregnancy category B.
There have been no adequate and well controlled studies concerning the safety of Acyclovir
in pregnant women. It should not be used during pregnancy unless the benets to the
patient clearly outweigh the potential risks to the fetus.
Acyclovir should only be administered to nursing mothers if the benets to the mother
outweigh the potential risks to the baby
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