Indication
ALEXID is indicated for the treatment of infections caused by mecillinam-sensitive organisms, e.g. acute cystitis, complicated urinary tract infections, salmonellosis, shigellosis. enteropathic E.coli diarrhoea, gram-negative septicaemia, biliary infections, yersiniosis.
Dosage & Administration
Adults: The usual dose is 1-2 tablets 3 times daily according to severity of the infections. In acute cystitis a treatment time of 3 days has been shown to provide high cure rates, whereas in complicated urinary tract infections the usual treatment time is 1-2 weeks. For prophylactic treatment of recurrent urinary tract infections 1 tablet every evening is recommended.
Children: Weighing less than 20 kg should be given 20-60 mg/kg 3-4 times daily into equally divided doses. Those weighing more than 20 Kg should receive normal adult dose. The tablets should be taken with at least 50-100 ml fluid. As the bioavailability is practically unaffected by simultaneous food intake, ALEXID tablets are best taken with or immediately after a meal.
Renal Impairment
Based on information available to data for patients with impaired renal function. the initial dose can remain unchanged and also can remain unchanged in the interval between doses. However, the amount administered as the maintenance dose should be changed according to the following criteria:
Side effects
ALEXID is generally well tolerated, even by patients with reduced kidney function. Gastro-intestinal disturbances in form of nausea, vomiting, and diarrhoea may occur. Skin rashes have been reported in some cases, but the characteristic ampicillin-rash has never been observed nor has there been any evidence of hepato- nephro- or ototoxicity. The occurrence of anaphylaxis, though not yet reported, but it cannot be entirely excluded.
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