Alton 20mg 5pcs

Presentation
Alton 20: Each enteric-coated tablet contains Esomeprazole 20 mg (as Esomeprazole Magnesium Trihydrate USP).
Alton 40: Each enteric-coated tablet contains Esomeprazole 40 mg (as Esomeprazole Magnesium Trihydrate USP).
Alton 40 IV Injection: Each vial contains Esomeprazole INN 40 mg (as lyophilized powder of Esomeprazole Sodium) and each ampoule contains 5 ml of 0.9% Sodium Chloride BP Injection.

Pharmacodynamics
Esomeprazole is the S-isomer of Omeprazole. It acts as a proton pump inhibitor that suppresses
gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting
specifically on the proton pump, Esomeprazole blocks the final step of acid production, thus
reducing gastric acidity.
Pharmacokinetics

Absorption
Bioavailability is approximately 90% (repeated once daily dosing) and 64% (single dose).
Distribution
Esomeprazole is 97% bound to plasma proteins. The apparent volume of distribution at steady state
in healthy volunteers is approximately 16 L.
Metabolism
Esomeprazole is extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme
system.

Excretion
Esomeprazole is excreted as metabolites primarily in urine but also in feces. Less than 1% of parent
drug is excreted in the urine.

Indications
Alton is indicated for-
• Risk Reduction of NSAID-associated gastric ulcer & duodenal ulcer
• Treatment of gastro esophageal reflux disease (GERD)
• Healing of erosive esophagitis
• Peptic ulcer diseases (PUD)
• H. pylori eradication (Triple therapy)
• Zollinger-Ellison syndrome