Indications
Hypertension: Amlodipine is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
Stable angina: Amlodipine is indicated for the treatment of chronic stable angina. It may be used alone or in combination with other antianginal agents.
Vasospastic angina: Amlodipine is indicated for the treatment of confirmed or suspected vasospastic angina. The drug may be used as single therapy or in combination with other antianginal drugs.
Therapeutic Class
Amlodipine is contraindicated in patients with–
1. Hypersensitivity to amlodipine, dihydropyridine derivatives or any of the excipients
2. Shock (including cardiogenic shock)
3. Obstruction of the outflow-tract of the left ventricle (e.g. high grade aortic stenosis)
4. Unstable angina
5. Hemodynamically unstable heart failure after acute myocardial infarction (during the first 28 days)
6. Severe hypotension
Side Effects
Pregnancy & Lactation
Pregnancy Category C. The safety of amlodipine in human pregnancy has not been established. In animal studies, reproductive toxicity was observed at high doses. Use in pregnancy is only recommended when there is no safer alternative and when the disease itself carries greater risk for the mother and fetus.
Lactation: It is not known whether amlodipine is excreted in breast milk. A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with amlodipine should be made taking into account the benefit of breast-feeding to the child and the benefit of amlodipine therapy to the mother.
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